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Rima Sutiono, Dias
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Therapeutic Effect of Avocatin B in Avocados Toward Acute Myeloid Leukemia Rima Sutiono, Dias; Ryan Pantoni, Anthony
Cermin Dunia Kedokteran Vol 45, No 11 (2018): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.75 KB) | DOI: 10.55175/cdk.v45i11.564

Abstract

Acute myeloid leukemia is the abnormal division of immature myeloid precursor cells in the bone marrow affecting mostly older people. Till date, there are no potent treatments due to the fact that it cannot target leukemic stem cells which are responsible for relapse and initiation of leukemia. Current treatments can also pose side effects that might to be too harsh for older people. Avocatin B is a lipid derived from avocado that can be a novel potent drug to replace or go along with the current therapies. Avocatin B is able to induce leukemic cell death and their stem cells while leaving normal cells unharmed. Their mechanisms of actions include inhibiting fatty acid oxidation which causes reactive oxygen species mediated apoptosis and lipotoxicity. Their selectivity towards leukemic cells over normal cells are due to the fact that they are able to target leukemic mitochondria which are different from the normal cells’ mitochondria in terms of their metabolic pathways.Leukemia myeloid akut merupakan sel precursor myeloid dalam sumsum tulang dewasa yang abnormal. Hingga saat ini, belum ada terapi yang tepat untuk leukemia myeloid akut. Avocatin B adalah lipid yang berasal dari alpukat, dapat menjadi obat baru atau digabungkan dengan terapi saat ini. Avocatin B mampu menginduksi kematian sel leukemia dan sel induknya. Mekanisme Avocation B meliputi penghambatan oksidasi asam lemak yang menyebabkan oksigen reaktif memediasi apoptosis dan lipotoksisitas. Selektivitas avocatin B terhadap sel-sel leukemia karena dapat menarget mitokondria penderita leukemia yang berbeda jalur metabolisme dari mitokondria sel-sel normal.
Wilson’s Disease: Current Therapies, Its Controversies, and Potential New Therapeutics Rima Sutiono, Dias; Syafitri Sudiro, Giardani
Cermin Dunia Kedokteran Vol 45, No 1 (2018): Suplemen
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.793 KB) | DOI: 10.55175/cdk.v45i1.164

Abstract

Wilson’s Disease is a rare genetic disorder with the prevalence of 1 in every 30,000 people, due to the mutation of the ATP7B gene responsible for copper metabolism. The mutation causes copper accumulation in the body, especially in the liver and brain, which leads to hepatic, neurological, psychological symptoms. These symptoms, if not treated properly, may lead to death after several years. Several treatments including low copper diet, zinc salts treatment, chelating agents (penicillamine, trientine, ammonium tetrahimiolybdate), and liver transplant are currently available. Severe neurological deterioration and other side effects need new, more efficient, and safer therapeutics. Several new therapeutic agents including 4-phenylbutyrate, curcumin, chelating polymeric beads, and long term metabolic correction have been tested in vitro and in vivo. These new therapeutics may be a potential new treatment with less side effect and greater efficacy for Wilson’s Disease patients.
Hypnosis for Pain Alleviation: Placebo or Nocebo? Rima Sutiono, Dias; Putra Gunawan, Jeremy; Devina, Astrella; Sindjaja, Wibi; Pavita, Jesslyn
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.779 KB) | DOI: 10.55175/cdk.v46i2.527

Abstract

The use of hypnosis to alleviate pain had started to gain recognition. In the assessed papers, application of hypnosis has included childbirth, surgeries, and chronic pain. In childbirth, the use of self-hypnosis can reduce the use of analgesics from 78% to 45% of cases. The satisfaction of hypnobirthing—birth using hypnosis—reaches 96%. Hypnosis can decrease the use of anesthesia drugs during surgery, promotes healing, decreases bleeding and hospital stay. Hypnosis can alleviate pain and reduce the use of over the counter painkillers; also showed benefits for non-cardiac chest pain relief while also reduces medication. Currently, hypnosis had been the most prominent application for labour pain relief. There is a demand for more studies of bioinformatics and neuroscience.Penggunaan hipnosis untuk mengurangi rasa sakit sudah mulai mendapat pengakuan. Banyak pustaka menjelaskan penerapan hipnosis pada proses melahirkan, operasi, dan nyeri kronis. Pada proses melahirkan, self-hypnosis dapat mengurangi penggunaan analgesik dari 78% menjadi 45% kasus. Kepuasan hypnobirthing – kelahiran menggunakan hipnosis - mencapai 96%. Hipnosis dapat mengurangi penggunaan obat anestesi, mempromosikan penyembuhan, mengurangi perdarahan dan lama rawat di rumah sakit pasca-operasi. Hipnosis bisa mengurangi penggunaan obat penghilang nyeri; juga menunjukkan manfaat untuk penderita nyeri dada non-jantung selain mengurangi konsumsi obat. Saat ini, aplikasi hipnosis yang paling menonjol untuk nyeri persalinan. Diperlukan studi bioinformatika dan neuroscience lebih lanjut.
Co-Authors Devina, Astrella Pavita, Jesslyn Putra Gunawan, Jeremy Ryan Pantoni, Anthony Sindjaja, Wibi Syafitri Sudiro, Giardani