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Pathni, Pande Made S. Dharma
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Health Professions Medicine & Pharmacology Public Health

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Terapi Diabetes dengan SGLT-2 Inhibitor Pathni, Pande Made S. Dharma
Cermin Dunia Kedokteran Vol 46, No 6 (2019): Diabetes Mellitus
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1226.346 KB) | DOI: 10.55175/cdk.v46i6.471

Abstract

SGLT-2 adalah transporter glukosa yang terletak di tubulus proksimal ginjal dan bertanggung jawab terhadap 90% reabsorpsi glukosa. Inhibisi terhadap transporter ini akan berdampak pada penurunan kadar glukosa darah dengan cara meningkatkan ekskresi glukosa melalui ginjal, namun kerjanya tergantung kadar glukosa.SGLT-2 is a glucose transporter located at renal proximal tubules and is responsible for 90% glucose reabsorption. Inhibition to this transporter resulted in a decrease of blood glucose through increased renal glucose excretion, but the action is dependent on blood glucose level.
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