Sujana, Karlina Sari
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Efektivitas N-Acetylsistein pada Pasien COVID 19 Sujana, Karlina Sari; Maulida, Munfika
Cermin Dunia Kedokteran Vol 48, No 7 (2021): Infeksi - [Covid - 19]
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.864 KB) | DOI: 10.55175/cdk.v48i7.1458

Abstract

COVID- 19 disebabkan oleh virus SARS-Cov-2 dan menyebabkan morbiditas dan mortalitas yang tinggi. COVID 19 dapat menyebabkan pneumonia, sindrom gangguan pernapasan akut, perubahan kardiovaskular, dan kegagalan multi organ, yang dianggap berasal dari mekanisma badai sitokin, respons peradangan sistemik, dan serangan sistem kekebalan. N-acetylcysteine (NAC) telah digunakan dalam klinis untuk mengobati pasien sepsis dengan kondisi kritis. NAC memiliki karakteristik antioksidan, antiinflamasi, dan modulasi kekebalan yang bermanfaat menurunkan risiko perburukan COVID-19.COVID-19 is caused by SARS-Cov-2 virus, and is known to cause high morbidity and mortality. COVID-19 causes pneumonia, acute respiratory distress syndrome, cardiovascular changes, and multi-organ failure, correlated to cytokine storm mechanisms, systemic inflammatory responses, and immune system attacks. N-acetylcysteine (NAC) has been used in clinical practice to treat sepsis patients with critical conditions. NAC has antioxidant, anti-inflammatory, and immune modulation characteristics beneficial to reduce the risk of COVID-19 worsening.
Severe Leptospirosis Sukma, Fragma Ady; Mulida, Munfika; Sujana, Karlina Sari
Cermin Dunia Kedokteran Vol 48, No 11 (2021): Kardio-SerebroVaskular
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.872 KB) | DOI: 10.55175/cdk.v48i11.1556

Abstract

Leptospirosis disebabkan oleh bakteri spirochete, genus Leptospira. Leptospirosis terjadi umumnya di wilayah tropis dan subtropis dengan curah hujan tinggi. Di Indonesia, pada tahun 2010 dilaporkan 410 kasus leptospirosis dengan 46 kasus kematian (CFR 11,2%). Kasus. Laki-laki, 35 tahun, datang dengan gejala klinis syok disertai demam, conjunctival suffusion, nyeri tekan gastrocnemius, dan riwayat banjir di tempat kerja satu minggu sebelum keluhan muncul. Diagnosis leptospirosis berat berdasarkan kriteria Faine. Leptospirosis is caused by the spirochete bacteria, genus Leptospira. Leptospirosis particularly occurs in tropical and subtropical regions with high rainfall. In Indonesia, 410 cases of leptospirosis were reported with 46 deaths in 2010 (CFR 11,2%). Case. A 35-year-old male presented with clinical symptoms of shock accompanied by fever, conjunctival suffusion, gastrocnemius tenderness, and history of flooding at workplace one week before the onset of symptoms. Diagnosis of leptospirosis was based on Faine diagnostic criteria.
Episode Berulang Malaria: Laporan Kasus: Laporan Kasus Putri, Anindya Dwitiya; Rossiyah, Nella; Sujana, Karlina Sari; Lesmana, Suvianto Hendri
Cermin Dunia Kedokteran Vol 53 No 02 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i02.994

Abstract

Introduction: Residents in malaria-endemic areas may experience more than 1 episode of malaria even in 1 season. Case: A 29-year-old male with fluctuating fever for 3 days accompanied by chills. The patient had just returned from Papua about 3 weeks before. The patient has worked in Papua for 1 year and has had 5 episodes of malaria: 3 falciparum malaria and 2 vivax malaria. Two months before this current complaint, the patient was taking DHP and primaquine. The patient did not take any malaria prevention drugs before leaving for Papua. Atinitial examination, the temperature was 38.6oC with leukocytosis (13,580/μL). Peripheral blood malaria examination found Plasmodium vivax parasites, stages: trophozoite and gametocyte. Patients were given DHP therapy (dihydroartemisinin 40 mg + piperaquine phosphate 320 mg) 4 times a day for 3 days and primaquine 15 mg once a day. Discussion: On the second day of treatment or the fourth day since symptom onset, the clinical condition began to improve. On the fourth day of treatment or the sixth day since symptom onset, the patient had no complaints, and vital signs and physical examination were within normal limits. The patient was discharged after continuing primaquine 15 mg for the next 11 days. Conclusion: DHP therapy (dihydroartemisinin 40 mg + piperaquine phosphate 320 mg) 4 times a day for 3 days and primaquine once at 15 mg results in a radical curative effect.