Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Cermin Dunia Kedokteran
Tandiawan, Fedrick
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Pengaruh Varian Organic Cation Transporter 1 (OCT-1) terhadap Bioavailabilitas dan Intoleransi Metformin Tandiawan, Fedrick
Cermin Dunia Kedokteran Vol 44, No 7 (2017): THT
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.536 KB) | DOI: 10.55175/cdk.v44i7.754

Abstract

Metformin, suatu derivat biguanid merupakan agen terapi oral hiperglikemia untuk diabetes tipe 2. Respon individu terhadap metformin signifikan berbeda. Heterogenitas ini dapat dijelaskan oleh faktor genetik yang mempengaruhi transporter obat tersebut. Salah satunya adalah OCT1 yang diekspresikan di enterosit, sel hepar dan ginjal. Variasi genotipe, disfungsi OCT1 dan obat penghambat OCT1 dapat mempengaruhi bioavailabilitas metformin dan efek klinisnya.Metformin, a biguanid derivate is an oral antihyperglycemic drug for type 2 diabetes mellitus treatment. Response to metformin varies significantly at individual level. This heterogeneity may be explained by genetic factors that influence drug transporters. One of the transporters - OCT1, is expressed on enterocytes, hepatocytes, and kidney. Genotype variants, OCT1 dysfunction and OCT1 inhibitors may change the bioavailability of metformin and its clinical effects.
Co-Authors