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Salim, Sidharta
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Health Professions Medicine & Pharmacology Public Health

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Ivermectin as a Potential Therapeutic Agent for COVID-19 – case studies Wijaya, Natalia Sisca; Salim, Sidharta
Cermin Dunia Kedokteran Vol 47, No 7 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i7.601

Abstract

In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) started in Wuhan, China, and has since become a global threat to human health. To dates, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. Several types of drug as well as vaccination are still under investigation and clinical trials worldwide. Recently, a study demonstrated ~5000-fold reduction in SARS-CoV-2 virus at 48h in cell culture after a single treatment of ivermectin. A clinical study at University of Utah found that the administration of ivermectin during COVID-19 illness in hospitalized patients is associated with lower mortality and hospital length of stay. We report three confirmed cases of COVID-19 infection with significant improvement clinically and radiologically following treatment with single dose of ivermectin.Pada Desember 2019, wabah yang disebabkan oleh varian baru coronavirus (SARS-CoV-2) dimulai di Wuhan, China, dan saat ini telah menjadi ancaman global bagi kesehatan manusia.Hingga saat ini, respon dunia terhadap wabah COVID-19 masih terbatas pada pemantauan dan isolasi. Di seluruh dunia, beberapa jenis obat dan juga vaksinasi masih menjalani tahap investigasi dan uji klinis. Baru-baru ini, sebuah studi mendemonstrasikan bahwa satu dosis ivermectin mampu mengurangi ~5000-kali kadar SARS-CoV-2 virus dalam 48 jam pada kultur sel. Sebuah uji klinis di Universitas di Utah juga membuktikan bahwa ivermectin terbukti menurunkan angka mortalitas dan juga lama perawatan pasien COVID-19 rawat inap. Kami melaporkan tiga pasien dengan konfirmasi positif COVID-19 yang menunjukkan kemajuan signifikan klinis dan radiologis setelah pengobatan dengan satu dosis ivermectin.
Falciform Ligament Abscess in Adult, Resolving Without Surgical Treatment Sisca Wijaya, Natalia; Salim, Sidharta
Cermin Dunia Kedokteran Vol 47, No 1 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (957.54 KB) | DOI: 10.55175/cdk.v47i1.343

Abstract

Seorang wanita 59 tahun datang dengan keluhan nyeri perut, mual, muntah, penurunan berat badan dan massa epigastrik sejak satu bulan. Anamnesis, pemeriksaan fisik dan pemeriksaan penunjang mengarah kepada diagnosis keganasan lambung. Akan tetapi, adanya sekret purulen dari lokasi biopsi dan juga hasil biopsi yang menunjukkan infiltrasi PMN mencurigakan abses. Kultur pus menunjukkan E. coli. Pasien tidak menyetujui tindakan operasi sehingga diterapi konservatif menggunakan antibiotik cephalosporin generasi ke tiga sesuai pola resistensi dari hasil kultur. Setelah satu bulan pemberian antibiotik, abses sepenuhnya menghilang. Artikel ini mempresentasikan kasus pertama abses ligamentum falciform setelah enteritis; yang teratasi tanpa terapi bedah.A 59 year-old female presented with a one-month history of abdominal discomfort, nausea, vomiting, weight loss and a palpable mass on her epigastrium area. Initial history, physical examination and work up lead to a diagnosis of gastric malignancy. However; discharge of purulent secretion from the biopsy site and biopsy results of PMN infiltration leads to a diagnosis of abscess. Culture subsequently showed E. coli. The patient was not amenable to surgical procedure hence was treated with third generation cephalosporin antibiotic as guided by culture results. After one month of antibiotic treatment, the abscess was completely resolved. This case presents the first falciform ligament abscess following enteritis; resolving with a non-surgical approach.
Fanconi Syndrome and Osteomalacia Induced by Tenofovir Sabrina, Lissa; Salim, Sidharta
Cermin Dunia Kedokteran Vol 51 No 4 (2024): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i4.875

Abstract

Introduction: Tenofovir disoproxil fumarate (TDF), an antiviral nucleoside analog reverse transcriptase inhibitor, has been used for the treatment of HIV and HBV in the past decades. TDF nephrotoxicity has been reported and could lead to renal failure and Fanconi Syndrome (FS). Case: A 58-year-old female HBsAg carrier with TDF treatment since 2013 presented with osteomalacia. She had glucosuria, albuminuria, vitamin D insufficiency, hypophosphatemia, and occasional hypokalemia episodes. Laboratory results showed amino aciduria, which indicates renal tubulopathy. The diagnosis of Fanconi syndrome was confirmed. Withdrawal of TDF was followed by improvement. Conclusion: The acquired FS associated with TDF is reversible. The use of TDF-containing antiviral regimens should be followed by screening recommendations to detect early Fanconi syndrome.
Co-Authors Sabrina, Lissa Sisca Wijaya, Natalia Wijaya, Natalia Sisca