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Sutopo, Mediana
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Sirenomelia “The Mermaid Syndrome “ - Kasus Serial Sutopo, Mediana; Uli, Tiarma
Cermin Dunia Kedokteran Vol 44, No 5 (2017): Gastrointestinal
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.857 KB) | DOI: 10.55175/cdk.v44i5.799

Abstract

Sirenomelia adalah kelainan kongenital yang jarang, angka kejadiannya 0,8 – 1 kasus / 100.000 kelahiran. Sirenomelia bersifat lethal dan biasanya bayi meninggal setelah lahir akibat kelainan kongenital multipel. Etiologi dan patogenesis sirenomelia masih belum diketahui, diduga akibat defek formasi embrional saat pembentukan regio kaudal. Dalam satu tahun kami menemukan 2 kasus sirenomielia. Pada kasus pertama didapatkan gambaran ultrasonografi hipoplasia thorak dan anhidramnion. Pada kasus kedua didapatkan gambaran horseshoe kidney, tidak tampak vesika urinaria, anhidramnion dan penumpukan long bones daerah caudal (femur, tibia dan fibula). Kedua kasus dirujuk dalam keadaan lanjut (trimester dua dan tiga), Jila diketahui dini (pada trimester satu), dapat dilakukan terminasi kehamilan dini pervaginam sehingga dapat mengurangi morbiditas ibu.Sirenomelia is a rare congenital disorder, the incidence is 0.8-1 case/100,000 births. Sirenomelia is lethal, the baby usually die after birth due to multiple congenital anomaly. The etiology and pathogenesis of sirenomelia is suspected due to a defect in the embryonic formation of the caudal region. We found two cases of sirenomielia in a year. The first case was found with thoracic hypoplasia and anhidramnion. The second case was found with horseshoe kidney, without clear bladder appearance, anhidramnion and piled long bones the caudal region (femur, tibia and fibula ). Both cases were referred to our hospital in second and third trimesters of pregnancy. Identification in early stage can reduce maternal morbidity by earlier vaginal termination of pregnancy.
Telomerase Inhibitor: Promising Target Therapy for Cancer Kusuma, Diana; Aliya, Izza; Putra, Andre; Sutopo, Mediana
Cermin Dunia Kedokteran Vol 45, No 4 (2018): Cidera Kepala
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (839.94 KB) | DOI: 10.55175/cdk.v45i4.670

Abstract

The key to selectively targeting cancer cells is to exploit some basic differences with their normal precursors. One such difference is the activity of the enzyme telomerase. Some studies targeted telomerase and telomeres in order to block limitless replicative potential of cancer cells, providing a fascinating strategy for a broad-spectrum cancer therapy. Telomerase based therapies could be well tolerated and perhaps with minimal side effect on telomerase-competent stem cells.Kunci pengobatan selektif sel kanker adalah dengan memanfaatkan beberapa perbedaan mendasar antara prekursor sel kanker dengan sel normal tubuh. Salah satu perbedaannya adalah aktivitas enzim telomerase. Beberapa penelitian sudah menargetkan telomerase dan telomer sebagai target terapeutik untuk memblokir potensi replikasi sel kanker yang tak terbatas, sebagai strategi terapi kanker spektrum luas. Terapi berbasis telomerase ini dapat ditoleransi dengan baik dan memiliki efek samping minimal pada telomerase sel normal tubuh lainnya.
Co-Authors Aliya, Izza Kusuma, Diana Putra, Andre Uli, Tiarma