Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Cermin Dunia Kedokteran
Purba, Nur Adiba
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Pendekatan Klinis Pasien Transthyretin Cardiac Amyloidosis (ATTR-CA) Purba, Nur Adiba
Cermin Dunia Kedokteran Vol 48, No 9 (2021): Nyeri Neuropatik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.765 KB) | DOI: 10.55175/cdk.v48i9.1483

Abstract

Transthyretin Cardiac Amyloidosis (ATTR-CA) adalah penumpukan fragmen protein transthyretin di jaringan interstisial miokardium akibat salah lipat protein, menyebabkan kardiomiopati restriktif dan infiltratif karena penebalan dan kekakuan dinding jantung. Transthyretin sebagian besar diproduksi di hati, berbentuk tetramer dan berfungsi sebagai protein pembawa tiroksin (T4) serta holoretinol binding protein (HRP). Saat ini, pemeriksaan diagnostik metode non-invasif telah dikembangkan meskipun biopsi endomiokardium masih menjadi gold standard diagnosis. Diagnosis akurat sedini mungkin sangat berpengaruh terhadap keberhasilan serta penurunan angka morbiditas dan mortalitas.Transthyretin Cardiac Amyloidosis (ATTR-CA) is the accumulation of transthyretin protein fragment in myocardium interstitial tissue induced by misfolded protein, lead to thickening and stiffness cardiac muscles, causing restrictive and infiltrative cardiomyopathy. Transthyretin is produced mainly in the liver as tetramer and bonded both with thyroxine (T4) and holoretinol binding protein (HRP) as carrier protein. Diagnostic test with non-invasive methods have been developed recently although endomyocardial biopsy is still the gold standard. Early targeted diagnosis has huge impact for therapy management and decreasing patient’s morbidity and mortality.
Co-Authors