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Indra Lukito, Johan
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Health Professions Medicine & Pharmacology Public Health

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Tinjauan atas Glucagon-like peptide-1 receptor agonist Indra Lukito, Johan
Cermin Dunia Kedokteran Vol 47, No 8 (2020): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.609 KB) | DOI: 10.55175/cdk.v47i8.780

Abstract

GLP-1 receptor agonist secara struktur mirip hormon alami GLP-1 yang memiliki efek incretin, namun degradasinya dapat dicegah oleh DPP-4. Saat ini terdapat 8 jenis yang terdiri dari exenatide, exenatide ER, liraglutide, albiglutide, dulaglutide, lixisenatide, semaglutide injeksi, dan semaglitode oral. GLP-1 receptor agonist merupakan pilihan pengobatan DM tipe 2 baik sebagai tambahan maupun sebagai monoterapi.The GLP-1 receptor agonist is structurally similar to the natural hormone GLP-1 which has an incretin effect but prevented from breakdown by DPP-4. There are currently 8 types of GLP-1 : exenatide, exenatide ER, liraglutide, albiglutide, dulaglutide, lixisenatide, injection semaglutide , and oral semaglutide. GLP-1 receptor agonist is an option for the treatment of type 2 DM both as adjunctive and as monotherapy.
Antifungal Echinocandin Indra Lukito, Johan
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (526.797 KB) | DOI: 10.55175/cdk.v46i2.525

Abstract

Infeksi fungal invasif (IFI) masih menjadi penyebab utama morbiditas dan mortalitas pasien immunocompromised. Pilihan antifungal yang tersedia untuk IFI terbatas pada polyene, triazole, dan echinocandin. Echinocandin, yang terdiri dari caspofungin, micafungin, dan anidulafungin, merupakan golongan antifungal terbaru yang saat ini banyak digunakan untuk pengobatan IFI. Echinocandin memiliki beberapa keunggulan seperti aktivitas fungisidal yang poten terhadap sebagian besar spesies Candida, rendahnya resistensi, profil keamanan yang lebih baik serta interaksi dengan obat lain yang lebih sedikit.Invasive fungal infection (IFI) is still a major cause of morbidity and mortality in immunocompromised patients. The antifungal choices available for IFI are limited to polyene, triazole, and echinocandin. Echinocandin, which consists of caspofungin, micafungin, and anidulafungin, is the newest class of antifungal which is currently widely used for the treatment of IFI. Echinocandin has several advantages such as potent fungicidal activity against most Candida species, low resistance, better safety profile and fewer drug interaction.
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