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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Cermin Dunia Kedokteran
Fernandi, Ryan
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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Efek Kafein terhadap Kesehatan Manusia Fernandi, Ryan
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.003 KB) | DOI: 10.55175/cdk.v46i1.545

Abstract

Kafein merupakan bahan alami yang paling banyak dikonsumsi di seluruh dunia, dapat ditemukan dalam berbagai produk makanan, minuman, serta obat-obatan. Saat ini minum kopi sudah menjadi tren dan kebiasaan bagi warga masyarakat khususnya di kota-kota besar, sehingga mendorong peningkatan konsumsi kopi yang kandungan utamanya adalah kafein. Kafein memiliki berbagai efek menguntungkan ataupun merugikan pada tubuh manusia. Efek jangka panjangnya masih kontroversial, pengaruhnya berbeda-beda tergantung pada metabolisme individu. Peningkatan kadar serum kolesterol, LDL, konsentrasi homosistein, dan tekanan darah merupakan beberapa efek merugikan, sedangkan penurunan risiko diabetes melitus tipe 2 dan berbagai kanker merupakan efek menguntungkan.Caffeine is the most consumed natural ingredient in the world, found in a wide variety of food products, beverages, and medicines. Drinking coffee has become a trend and habit, especially in cities, thus encouraging increased consumption of coffee and caffeine as its main content. Caffeine is known to have both beneficial and adverse effects on the human body; may vary, depending on the individual metabolism. Increased serum cholesterol levels, LDL, homocysteine concentrations, and blood pressure are several adverse effects, while decreasing the risk of type 2 diabetes mellitus and various cancers is a beneficial effect.
Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats Fernandi, Ryan; Sudartana, I Ketut; Sueta, Made Agus Dwianthara; Mahayasa, I Made; Yasa, Ketut Putu; Wibawa, I Gusti Agung Bagus Krisna
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.36698

Abstract

Peritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal saline versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesion following laparotomy in rats. In this post-test control group study, 20 adult Wistar rats were subjected to laparotomy before being randomly divided into two groups to receive either intraperitoneal lavage with normal saline (0.9% NaCl) or sterile water. After 7 days, IL-1 level and degree of adhesion were evaluated. The saline group had higher adhesion levels (4 rats with grade 4, 5 with grade 3, 1 with grade 2) than the sterile water group, which had lower levels (2 rats with grade 3, 5 with grade 2, 3 with grade 1). There was a significant difference in IL-1 levels between the sterile water group (37,111.6 ± 6,535.61 pg/ml) and the normal saline group (57,456.3 ± 10,583.41 pg/ml). There was a significant correlation between IL-1 levels and adhesion grade (p=0.008). Intraperitoneal lavage with sterile water results in significantly lower adhesion grade and IL-1 levels than normal saline, suggesting its potential for reducing postoperative adhesions. Further studies are needed to elucidate the mechanism of reduced adhesion and inflammation associated with sterile water lavage.
Co-Authors Ketut Putu Yasa Mahayasa, I Made Sudartana, I Ketut Sueta, Made Agus Dwianthara Wibawa, I Gusti Agung Bagus Krisna