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All Journal JURNAL PENDIDIKAN TAMBUSAI Cermin Dunia Kedokteran Cerdika: Jurnal Ilmiah Indonesia
Christian Yong, Bernard Jonathan
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Humanities Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Penggunaan Parasetamol pada Covid-19 Christian Yong, Bernard Jonathan
Cermin Dunia Kedokteran Vol 48, No 7 (2021): Infeksi - [Covid - 19]
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.71 KB) | DOI: 10.55175/cdk.v48i7.1457

Abstract

Latar belakang: Parasetamol sering digunakan untuk mengobati gejala demam pada COVID-19. Banyak hipotesis yang menyebutkan hubungan kadar Glutathione (GSH) dengan derajat keparahan COVID-19, sedangkan parasetamol dapat menurunkan kadar GSH. Hingga saat ini, belum ada panduan khusus untuk dosis penggunaan obat parasetamol pada pasien COVID-19.Background: Paracetamol is often used to treat fever symptoms in COVID-19. Many hypotheses state the relationship between Glutathione (GSH) levels and the severity of COVID-19, while paracetamol can reduce GSH levels. To date, there are no specific guidelines for the dosage of paracetamol in patients with COVID-19 
Profil Fungsi Ginjal Pasien Covid-19 Derajat Berat dengan Acute Kidney Injury terhadap Mortalitas di Unit Perawatan Intensif Christian Yong, Bernard Jonathan; Dermawan, Kenneth
Jurnal Pendidikan Tambusai Vol. 6 No. 1 (2022): 2022
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v6i1.3683

Abstract

Peningkatan kasus Covid-19 menjadikan perawatan di unit perawatan intensif sebagai upaya dalam penanganan kasus Covid-19 dengan derajat berat dan kritis. Beberapa penelitian menunjukkan bahwa reseptor ACE-2 tidak hanya terdapat di paru-paru melainkan ditemukan juga di ginjal. Infeksi virus Covid-19 dapat menyebabkan gagal ginjal akut yang ditandai dengan adanya peningkatan nilai ureum dan kreatinin. Beberapa studi menunjukkan insiden Acute Kidney Injury (AKI) pada pasien Covid-19 yang dirawat di ruang perawatan intensif cukup tinggi yaitu 2.9% - 29%. Tujuan penelitian ini memberikan gambaran fungsi ginjal pasien Covid-19 derajat berat dan kritis saat masuk ke unit perawatan intensif serta melihat persentase yang mengalami AKI terhadap mortalitas. Penelitian deskriptif retrospektif dilakukan di RS UKRIDA terhadap 168 pasien Covid-19 derajat berat dan kritis yang dirawat di Unit Perawatan Intensif dengan periode bulan Desember 2020 - September 2021. Data penelitian diambil dari rekam medis elektronik dan disajikan dalam bentuk tabel dan grafik. Analisis data menggunakan Microsoft Excel dan SPSS MacOS versi 23. Hasil penelitian menunjukkan usia rata-rata 59.74 ± 12.46 tahun, laki-laki sebanyak 93 pasien (55.3%) dengan rerata IMT adalah 27.24 ± 4.73. Komorbid paling sering ditemukan adalah hipertensi dengan jumlah 94 pasien (55.9%). Kadar kreatinin baseline (1.08 ± 0.63), kadar ureum (55.82 ± 43,15) dan kreatinin (1.12 ± 0.74) saat admisi di unit perawatan intensif. Prevalensi AKI adalah 10.7% dengan tingkat mortalitas AKI berdasarkan GFR adalah 63.6% dan berdasarkan serum kreatinin adalah 77.8% Badai sitokin yang terjadi akibat infeksi virus Covid-19 dapat berdampak langsung maupun tidak langsung pada ginjal sehingga pasien AKI yang berat dapat meningkat mortalitas pasien Covid-19. Deteksi dini AKI dan intervensi terapi pengganti ginjal yang dilakukan secara cepat dan tepat dapat meningkatkan luaran yang baik.
Chronic Pulmonary Aspergillosis in a Post-treated Tuberculosis Patient Christian Yong, Bernard Jonathan; Gunarsa, Ralph Girson
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 5 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v2i5.387

Abstract

Chronic Pulmonary Aspergillosis (CPA) is a progressive respiratory syndrome of severe fungal infection typically found in immunocompetent or slightly immunocompromised patients with an underlying pulmonary disease. The underlying pulmonary disease typically includes active or post-tuberculosis, chronic obstructive pulmonary disease, or a history of surgery for lung cancer, for which tuberculosis remains the most common underlying condition. A 60 years old woman came with worsening dyspnea for the last 1 week, with hemoptysis and weight loss for the last 3 months, she has a history of pulmonary tuberculosis for 39 years, which was fully treated and she had completed the treatment regimen. A computed tomography (CT) scan was conducted, which showed solid fibroxanthoma with an air bronchogram in the upper left lung area. Transthoracic lung biopsy showed hyphae and fungal spores of Aspergillosis, which was supported by a positive Galactomannan test. Eventually, she was diagnosed with pulmonary aspergillosis and was advised to undergo surgical treatment with left pneumonectomy, but the patient refused surgical treatment. Chronic pulmonary aspergillosis is a progressive respiratory condition of severe fungal infection and is mostly found in post-tuberculosis patients. The symptoms may be similar to other chronic pulmonary diseases, making the diagnosis difficult. There are several reports that said pulmonary aspergillosis was misdiagnosed and only diagnosed only on autopsy. The mortality rate of this condition is quite high, and it typically worsens the quality of life.
Co-Authors Dermawan, Kenneth Ralph Girson Gunarsa