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All Journal Jurnal Syntax Fusion : Jurnal Nasional Indonesia KESANS : International Journal of Health and Science
Dela Pebrianti, Mariska
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Chemistry Education Engineering Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Physics Public Health Social Sciences

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Trombositosis Esensial Dela Pebrianti, Mariska
Jurnal Syntax Fusion Vol 2 No 01 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : CV RIFAINSTITUT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i01.142

Abstract

Trombositosis esensial adalah kelainan klonal sel induk hematopoietik multipotensial pada jalur megakariosit dan trombosit. Pada tahun 1920 Guglielmo dan Epstein dan pada tahun 1934 Goedel pertama kali melaporkan temuan trombositosis esensial yang dianggap sebagai bagian dari penyakit mieloproliferatif yang lain. Pada tahun 1960 trombositosis esensial ditentukan sebagai suatu penyakit mieloproliferatif yang berbeda. Pada tinjauan pustaka ini akan dibahas terkait definisi, etiologi, patofisiologi, gambaran klinis, diagnosis, komplikasi, dan tatalaksana trombositosis esensial. Tujuan penelitian ini untuk mengetahui definisi, etiologi, patofisiologi, gambaran klinis, diagnosis, komplikasi, dan tatalaksana trombositosis esensial. Penelitian ini menggunakan berbagai jenis sumber artikel. Pencarian artikel dilakukan di portal online publikasi jurnal seperti National Center for Biotechnology Information / NCBI (ncbi.nlm.nih.gov) dan Google Scholar (scholar.google.com). Adapun kata kunci yang digunakan adalah “Trombositosis Esensial “, “Trombosis”, “Essential Trombositosis” dan “Thrombosis”. Kesimpulan yang bisa ditarik yaitu trombositosis esensial merupakan kelainan mieloproliperatif yang disebabkan kelainan klonal sel induk hematopoietik multipotent akibat mutasi gen JAK2, CALR, dan MP. Pengobatan pada penyakit ini dengan pemberian obat-obat seperti aspirin dengan dosis rendah dan obat sitoreduksi pada pasien risiko tinggi.
The Role of Folic Acid in Stroke Prevention Anditya Almanda Zefanya, Alvin; Dela Pebrianti, Mariska
Jurnal KESANS : Kesehatan dan Sains Vol 1 No 3 (2021): KESANS : International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v1i3.20

Abstract

Stroke is one of the most serious health problems faced today. This is because a sudden stroke can cause physical and mental disabilities that can interfere with a person's productivity and can even cause sudden death. Stroke can be divided into two, namely hemorrhagic stroke and non-hemorrhagic stroke. Hemorrhagic stroke is a stroke that occurs due to damage to blood vessels in the brain. While non-hemorrhagic stroke, also known as ischemic stroke, occurs when the blood supply to the brain is interrupted or stopped. About 80% of the most common strokes are caused by an ischemic stroke. One of the causes of ischemic stroke due to atherosclerotic plaque. Elevated levels of homocysteine ??in the blood (hyperhomocysteinemia) can lead to chronic inflammation of the blood vessels that triggers the formation of atherosclerotic plaques and causes blockage of blood flow. Folic acid is a type of water-soluble vitamin and can play a role in preventing stroke. Folic acid can act as an antihomocysteine ??so that it can prevent the formation of atherosclerotic plaques which is one of the risk factors for stroke
Co-Authors Anditya Almanda Zefanya, Alvin