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All Journal JSMARTech : Journal of Smart Bioprospecting and Technology Indonesian Journal of Pharmacology and Therapy
Abimanyu, I Gede Agni Marwan
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Spirulina platensis’s phycocyanobilin as an antiangiogenesis by inhibiting VEGFR2-VEGFA pathway in breast cancer: in silico study Jayanti, Dewa Ayu Putu Ismartati Sukma; Abimanyu, I Gede Agni Marwan; Azzamudin, Haidar
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 3 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.03.87

Abstract

Breast cancer is a cancer type that leads to many women deaths. The causes are from the primary tumour and other progressions such as metastatic and angiogenesis. Some therapy strategies have been developed to treat breast cancer, but they are not good enough for treating breast cancer progressions. Spirulina platensis has a phycocyanin and a phycocyanobilin, known as antioxidant and antiinflammatory bioactivities. This study identified anticancer activity of phycocyanobilin from Spirulina platensis. We also investigated the phycocyanobilin mechanism in breast cancer inhibition through VEGFR2-VEGFA pathway. In silico analysis was conducted the inhibition modelling of phycocyanobilin to the VEGF-VEGFR pathway. The VEGF and VEGFR proteins were taken out from Protein Data Bank (PDB) database and were prepared with BIOVIA Discovery Studio 2019. Phycocyanobilin as a ligand was obtained from PubChem and prepared with PyRx. The molecular docking was conducted using HEX 8.0.0 CUDA and the last step is the protein-ligand complexes were visualized and analyzed using BIOVIA Discovery Studio 2019. It results in five protein-ligand complexes in which the receptor-ligand complex VEGFR2-[VEGFA-phycocyanobilin] can inhibit the angiogenesis process by phycocyanobilin binds to VEGFA, and it prevents the angiogenesis process by blocks the VEGFR2 and stops VEGFA to bind with VEGFR2. Thus phycocyanobilin has potential as an anticancer agent especially in  breast cancer as an antiangiogenesis.
Ethical consideration of gene therapy in Indonesian HIV patients and its management: A narrative review Abidin, Ali Zainal; Lessy, Nina Sakina; Widiastuti, Melina Ayu; Abimanyu, I Gede Agni Marwan; Ramadhan, Raka Kurnia
Indonesian Journal of Pharmacology and Therapy Vol 6 No 3 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.13288

Abstract

Human Immunodeficiency Virus (HIV) infection remains a major global health issue, including in Indonesia. Gene therapy (GT) has emerged as a promising therapeutic approach for various diseases, including HIV. However, its application also raises significant ethical challenges, particularly within the Indonesian context. This article aims to explore the ethical considerations, potential, and challenges of implementing GT for patients with HIV in Indonesia. A comprehensive narrative review was conducted by examining currentscientific literature and ethical frameworks related to GT and HIV management, with a focus on clinical feasibility, safety, and social implications within the Indonesian context. Gene therapy technologies such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and ClusteredRegularly Interspaced Short Palindromic Repeats (CRISPR) have shown promising potential in suppressing HIV infection. However, concerns remain regarding onand off-target effects that may cause genomic instability and oncogenesis. Ethical challenges include the high cost of therapy, limited public understanding of GT,and the absence of specific regulations governing its application in HIV treatment. Indonesia’s diverse sociocultural landscape further complicates equitable access and acceptance of this advanced technology. The implementation of GT for HIV in Indonesia requires careful ethical consideration, transparent communication,and robust policy development. Establishing national guidelines and conducting further research are essential to ensure that the adoption of GT is safe, equitable, and ethically responsible within the Indonesian healthcare system.
Co-Authors Ali Zainal Abidin Azzamudin, Haidar Jayanti, Dewa Ayu Putu Ismartati Sukma Lessy, Nina Sakina Ramadhan, Raka Kurnia Widiastuti, Melina Ayu