Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Indian Journal of Forensic Medicine & Toxicology
Magdivari Sangeetha
Unknown Affiliation
Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Synthesis, Characterization, Molecular Docking of Sulphamethoxazole Schiff Base Metal Complexes and Its Antibacterial, Anti-Inflammatory and Anti Depressant Activity R.Gandhimathi; Magdivari Sangeetha
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17413

Abstract

In our study we have a tendency to synthesized schiff’ base of bactericide drug sulphamethoxazole on treating with aromatic aldehydes like p-diethyl amino benzyldehyde and p-dimethyl amino benzyldehyde. The synthesized schiff’s bases were regenerate to its ion Schiff bases by treating with methyl group halide. The ion Schiff bases were regenerate to metal complexes by treating with metals like CuCl2, ZnCl2 and CdCl2. All the synthesized compounds were characterised by Elemental analysis, IR andH proton magnetic resonance. Docking study was performed to know the interaction of binding sites with protein receptor using MAO-B enzymes (PDB ID: 2BK5) and COX-2 enzyme (PDB ID: 5IKR) by Virtual Screening software for Computational Drug Discovery. Synthesized metal complexes were evaluated for antibacterial, anti inflammatory and antidepressant activity. Copper metal complexes showed potent antibacterial and anti-inflammatory activity. Significant anti-depressant activity was shown for 2A2 and 2B2 zinc metal complexes
Co-Authors R.Gandhimathi