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All Journal Indian Journal of Forensic Medicine & Toxicology
Asaad AbdulAmeer Khalaf
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Public Health

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The Role of Soluble HLA-G Serum Level in Therapeutic Response of Chronic Myeloid Leukemia Patients Zainab Khalid Khaleel; Hayfaa Salman Al-Hadithi; Asaad AbdulAmeer Khalaf; Omran Sukar Habib
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17675

Abstract

Human leukocyte antigen-G molecules (HLA-G) have been suggested to play a role in immune evasion and progression of different malignancies by their tolerogenic activity, through interaction with inhibitory receptors on surface of immune cells.The aim is to evaluate the role of the s HLA-G serum level in the prognosis and therapeutic responses to TKIs in CML patients.Serum level of soluble HLA-G was measured for a total of 61 adult patients with CML, who were on regular TKI for at least 6 months whom attended the out-patient’s clinic of the Hematology Center in Basra, compared with 20 apparently healthy controls matched in ages and sexes to the patients using Enzyme Linked Immuno-Sorbent Assay (ELISA) technique.Serum levels of HLA-G in CML patients was significantly higher than that in healthy controls (p=0.006). Elevated serum level of s HLA-G was significantly correlated with sex, BMI, duration of disease, Sokal scoring system.On the other hand, low s HLA-G serum level was significantly correlated with event free status (EF) of CML patients.Lower level of serum soluble HLA-G in CML patients compared to healthy controls and it might be proved as a prognostic biomarker for CML patients.
Co-Authors Hayfaa Salman Al-Hadithi Omran Sukar Habib Zainab Khalid Khaleel