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All Journal Indian Journal of Forensic Medicine & Toxicology
Manal K Rasheed
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Thiopurine S-Methyltransferase Genotyping in Iraqi Childhood Acute Lymphoblastic Leukemia Patients ; A Single Institute Study Esraa Ali Kadhum; Manal K Rasheed; Hasanein H.Ghali
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17805

Abstract

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer seen in childrenworldwide and is the most common cancer in children under 14 years of age. Although there havebeen major advances in treatment approaches for childhood ALL, serious toxicities such as profoundleukopenia frequently affect treatment and lead to life threatening consequences such as severeinfections and even death. There has been a lot of interest in inter-individual differences in drugmetabolizing enzymes in order to better adjust drug dosage and therapy. In this regards, ThiopurineS-Methyltransferase (TMPT) was the first pharmacogene that showed a substantial associationwith Mercaptopurine (6-MP) maximum tolerated dose and 6-MP related toxicities leading to theimplementation of TPMT genotyping before drug administration Aim: To identify the most commonTPMT polymorphism (TPMT*3A, TPMT*3B and TPMT*3C) and its frequencies in a sample of IraqiALL paediatric patients. Methods: A cross sectional study was performed for 79 patients with Acutelymphoblastic leukemia . Genotyping for (*3A , *3B , *3C ) the TPMT gene was performed by theallele-specific multiplex-PCR analysis method. Results: The TPMT*3A mutant allele was found in 18patients with allele frequency of (22.8 %), while TPMT*3C mutant allele was detected in 5 childrenwith allele frequency of 6.3% . But TPMT*3B mutant allele was not detected in whole sample ALLpatients .The correlation between gender and the polymorphism was not statically significant as p-value0.23.. Conclusion: TMPT genotyping is an essential tool to reduce the cytotoxic effects of the anticancerdrug 6-MP in Iraqi paediatric patients with ALL .
The Relation between the Plasma Level of Testosterone Hormone and the Severity of COVID-19 in Iraqi Patients Rusul A. Abass; Manal K Rasheed; Ghassan T. Saeed
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17983

Abstract

Coronavirus disease 2019 discovered in December 2019, Wuhan, China. It was transmitted globally producing the present COVID-19 pandemic. Concerns have been raised about the potential impact of COVID-19 on male reproductive organs and male fertility as the number of infections in the male community has increased. The objectives of current study are studying the relationship between the plasma levels of testosterone and the markers of immune reaction with the severity and mortality in a sample of COVID-19 patients. A cross section study included NO= 103 male patients affected by SARS- CoV-2 pneumonia, diagnosed by PCR and chest CT scan, (≥ 18 years old), and recovered in the respiratory intensive care unit (RICU). Several biochemical risk factors were determined Free Testosterone, sex hormone binding globulin (SHBG) were measured by Enzyme-Linked Immunosorbent Assay(ELISA), D-dimer, Ferritin, CRP, Urea, Creatinine were measured by automated method by using Abbott Architect c4000 and Complete Blood Count(CBC). The results show that the serum free testosterone and SHBG levels a significant lower in non-survivor patients than survivor patients with COVID-19. While the other biomarkers (D-dimer, Ferritin, Urea, Creatinine) were significant higher in non-survivor patients than survivor patients. The CRP, WBC and lymphocyte showed that no significant between the both group of patients. In conclusion the study showed that lower free testosterone and SHBG levels enable significant role in increasing risk of COVID-19 mortality amongst adult male patients
Co-Authors Esraa Ali Kadhum Ghassan T. Saeed Hasanein H.Ghali Rusul A. Abass