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Tambusai, Sofia Rahmi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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ACTIVITY TEST OF SIAM LABU (Sechium edule (Jacq.) Swartz) LEAF EXTRACT ON REDUCTION OF DARAGE URATE ACID TARGETS OF WHITE RATS (Rattus novergicus) Tambusai, Sofia Rahmi
JBIO: jurnal biosains (the journal of biosciences) Vol 9, No 3 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i3.51002

Abstract

Uric acid is a substance produced from the breakdown of purines or waste products in the body, as a result of purine catabolism aided by the enzymes cguanase and xanthine oxidase. One of the green plants  used as traditional medicine is siam labu (Sechium edule). This plant is a vegetable plant belonging to the Curcubatiacae family that grows in the highlands. The purpose of this study was to test the anti-gout activity of chayote leaves in male  rats. The method used in this study started from preparing simplisia, preparing siam labu leaf extract, inducing mice with Ca-oxanate at a dose of 250 mg/kgBW and administering siam labu leaf extract at a dose of 250 mg/kgBW, 500 mg/kgBW. and 750 mg/kgBW was administered orally with intermittent observation periods of 1 hour for 6 hours. Results obtained in rats given 750 mg/kgBW of extract showed the lowest reduction of 3.88 ± 0.3 mg/dl. One-way ANOVA results  obtained a significant value p=0.00 (p<0.05), which can be concluded that there are differences in each treatment method in experimental animals. Tukey test results can be seen at 6 hours, it can be concluded that EDLS 750 mg/kg body weight with allopurinol is not significantly different.
ACTIVITY TEST OF SIAM LABU (Sechium edule (Jacq.) Swartz) LEAF EXTRACT ON REDUCTION OF DARAGE URATE ACID TARGETS OF WHITE RATS (Rattus novergicus) Tambusai, Sofia Rahmi
JURNAL BIOSAINS Vol. 9 No. 3 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i3.51002

Abstract

Uric acid is a substance produced from the breakdown of purines or waste products in the body, as a result of purine catabolism aided by the enzymes cguanase and xanthine oxidase. One of the green plants  used as traditional medicine is siam labu (Sechium edule). This plant is a vegetable plant belonging to the Curcubatiacae family that grows in the highlands. The purpose of this study was to test the anti-gout activity of chayote leaves in male  rats. The method used in this study started from preparing simplisia, preparing siam labu leaf extract, inducing mice with Ca-oxanate at a dose of 250 mg/kgBW and administering siam labu leaf extract at a dose of 250 mg/kgBW, 500 mg/kgBW. and 750 mg/kgBW was administered orally with intermittent observation periods of 1 hour for 6 hours. Results obtained in rats given 750 mg/kgBW of extract showed the lowest reduction of 3.88 ± 0.3 mg/dl. One-way ANOVA results  obtained a significant value p=0.00 (p<0.05), which can be concluded that there are differences in each treatment method in experimental animals. Tukey test results can be seen at 6 hours, it can be concluded that EDLS 750 mg/kg body weight with allopurinol is not significantly different.
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