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All Journal Pediatric Sciences Journal Cermin Dunia Kedokteran
Wijaya, Lisa Amelia
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Health Professions Public Health

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Unveiling associated factors related to congenital heart disease in children: A case-control study Wijaya, Lisa Amelia; Yantie , Ni Putu Veny Kartika; Gunawijaya, Eka
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.125

Abstract

Background: Congenital heart diseases (CHDs) remain a significant global health burden and a leading cause of child mortality. However, limited evidence exists regarding the factors associated with CHDs, particularly in Indonesia. This study aims to identify factors associated with congenital heart defects (CHDs) in children. Methods: A case-control study was conducted using secondary data from pediatric cardiology patients at Ngoerah Hospital between 2021 and 2023, extracted from pedcardiobali.com. Patients aged 0–18 years who were diagnosed with CHD via echocardiography were included in the case group. Those with normal echocardiographic findings comprised the control group. Patients with incomplete medical records were excluded from the study. A total of 300 eligible subjects were selected, with 150 assigned to each group using a combination of purposive and random sampling methods. Multivariate logistic regression analysis was performed using SPSS version 29.0. Results: Among the 300 subjects, low birth weight (<2,500 grams) was significantly associated with CHDs (OR 3.365; 95% CI: 1.48–7.65; P = 0.004). Prematurity, maternal alcohol consumption, and congenital anomalies were identified as potential confounding factors (OR 1.19; 95% CI: 0.61–2.35; P = 0.61; OR 1.65; 95% CI: 0.45–6.06; P = 0.45; OR 1.98; 95% CI: 0.56–6.94; P = 0.29, respectively). No significant associations were found with maternal or paternal age, multiparity, multiple gestation, smoking, family history of CHDs, or maternal infection. Conclusion: Low birth weight is a dominant factor associated with CHDs. Early prenatal care and targeted interventions are crucial in reducing this risk. Further research is warranted to investigate the underlying mechanisms and genetic contributions to coronary heart disease (CHD).
Dengue Neonatal : Sebuah Laporan Kasus: Laporan Kasus Wijaya, Lisa Amelia; Trisnia, Putu Ayunda; Suarca, I Kadek
Cermin Dunia Kedokteran Vol 53 No 04 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i04.1833

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Introduction: Neonatal dengue is a rare but potentially lethal infectious disease, infected through maternal vertical transmission during pregnancy or via mosquito bites. Case: A 3-day-old, 3120-gram female neonate was admitted to the neonatal intensive care unit with fever and jaundice. Her mother was re-admitted for dengue infection 24 hours postpartum. The patient was hemodynamically stable, withno thrombocytopenia, and underwent phototherapy to treat jaundice (total bilirubin 15,7 mg/dL, indirect bilirubin 14,8 mg/dL). Neonatal dengue was diagnosed on the third day of admission since her temperature rose to 38,8oC and the NS1 antigen was reactive. The platelet count dropped from 257,000/mm3 to the lowest count of 15,000/mm3 on the sixth day of admission with the appearance of petechiae on her face, chest, back, and abdomen. No active bleeding was observed. Adequate treatment and close hemodynamic monitoring would lead to better outcomes. Discussion: Neonatal dengue is a rare condition that can occur through vertical transmission from the mother orhorizontal transmission via mosquito vectors, with diagnosis supported by tests such as the NS1 antigen or RT-PCR. Clinical manifestations in newborns vary widely, ranging from mild fever to severe complications such as thrombocytopenia, shock, and liver dysfunction. Conclusion: Neonatal dengue is a potentially lethal infectious disease. Early diagnosis and prompt treatment are needed, especially in endemic regions.
Co-Authors Eka Gunawijaya Suarca, I Kadek Trisnia, Putu Ayunda Yantie , Ni Putu Veny Kartika