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All Journal Current Biochemistry Molecular and Cellular Biomedical Sciences (MCBS) Acta Biochimica Indonesiana Asian Journal of Science Education
Ahsan, Haseeb
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Biochemistry, Genetics & Molecular Biology Dentistry Education Immunology & microbiology Medicine & Pharmacology Neuroscience Social Sciences Other

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The Role of Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP) in Patients with Hypertension Alam, Rohsan; Ahsan, Haseeb; Khan, Saba
Molecular and Cellular Biomedical Sciences Vol 7, No 2 (2023)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v7i2.288

Abstract

Oxidative stress contributes to the pathogenesis of hypertension and studies have shown that hypertension is associated with an increase in oxidative stress. Reactive oxygen species (ROS) lead to hypertension and antioxidants may be beneficial for its prevention. The main cause of oxidative stress in hypertension is endothelial dysfunction due to the malfunctions in the vasodilator systems, specifically the molecular mechanism of ROS and nitric oxide (NO). The level of malondialdehyde (MDA), a biomarker of lipid peroxidation and oxidative stress, is found to be higher in hypertension patients. Total antioxidant capacity (TAC), which has a strong relationship with blood pressure, is determined through the ferric reducing antioxidant power (FRAP). The aim of the review article is to elucidate the role of MDA and FRAP in hypertension.Keywords: oxidative stress, hypertension, blood pressure, oxidative damage, malondialdehyde, FRAP
Clinical Chemistry and Biochemistry: The Role of Biomarkers and Biomolecules AHSAN, HASEEB
Asian Journal of Science Education Vol 4, No 1: April, 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/ajse.v4i1.24431

Abstract

Biochemistry is a branch of biosciences which deals with the study of chemical reactions that occur in living cells and organisms. It is a subject in which biological phenomenon is analyzed in terms of chemical reactions or metabolic pathways. Biochemistry has been previously named as biological chemistry, chemical biology, clinical chemistry, chemical pathology, physiological chemistry, including medical biochemistry and clinical biochemistry. Medical biochemistry studies the chemical composition and physiological reactions in the human body. Clinical biochemistry is the measurement of chemicals or analytes in body fluids for the diagnosis, monitoring and management of patients with various diseases such as diabetes, cardiovascular diseases, etc. An increase in the number and availability of laboratory diagnostics has helped in the solution of clinical problems. Particularly important is the contribution of clinical chemistry to the diagnosis and monitoring of diabetes. The importance of lipids and lipoproteins for public health has increased with clinical studies showing the benefit of lipid lowering in cardiovascular diseases. An understanding of clinical chemistry and biochemistry would be useful in the study of medical and allied sciences for the advancement of knowledge in academic and professional courses. This review article is an attempt to understand the scope and significance of basic and applied aspects of biochemistry
A Brief Overview and History of Human Nutrition and Health Ahsan, Haseeb
Current Biochemistry Vol. 9 No. 2 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.2.5

Abstract

Nutritional biochemistry is finally getting the attention it deserves, despite the fact that food and nutrition have been studied for centuries. In 1926, less than 100 years ago, the first vitamin was extracted and chemically characterized, leading to studies on single-nutrient deficiency diseases. Nutritional research on chronic diseases like cardiovascular disease, diabetes, obesity, and malignancies has hastened in the past few decades, especially after the year 2000. Nutrition has played a key role in the improvement of public health since the past 200 years, and is expected to play a major role in public health for the future. Keywords: nutrition, diet, history, food, agriculture.
Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India Kidwai, Mohammad Zaid; Alam, Roshan; Ahsan, Haseeb; Khan, Mohammad Mustufa; Khan, Saba
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.84

Abstract

Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity.Aim: The study was designed to determine the malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow.Method: The oxidative stress was analyzed in T2DM patients as MDA. The total antioxidant capacity was estimated through the FRAP in T2DM patients and control subjects.Results: The level of MDA was observed to be higher (4.84 ± 1.09) in T2DM patients compared to controls (2.20 ± 0.85). The FRAP was lower among T2DM patients (509.46 ± 126.36) compared to controls (895.62 ± 179.92). The difference between FRAP in T2DM patients and controls was statistically significant (p=0.0001).Conclusion: MDA was found to be higher in T2DM, and the FRAP level was lower in T2DM patients compared to controls, signifying increased oxidative stress and decreased antioxidant level in T2DM patients.
Co-Authors Alam, Rohsan Alam, Roshan Khan, Mohammad Mustufa Khan, Saba Kidwai, Mohammad Zaid