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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Rheumatology
Perdana Aditya Rahman
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Medicine & Pharmacology

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Therapeutic Challenges in Systemic Lupus Erythematosus Patient with Pregnancy, Osteoporosis, and Severe Thrombocytopenia: A Case Report and Review of Literature Yosefin Ratnaningtyas; Perdana Aditya Rahman
Jurnal Kedokteran Brawijaya Vol. 31 No. 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.6

Abstract

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that requires long-term corticosteroid treatment that may lead to osteoporosis characterized by low bone mass and microarchitectural deterioration of the trabecular and cortical skeletal. This study presents a severe case of thrombocytopenia in a 25-year old woman with SLE and osteoporosis who underwent routine therapy and was pregnant for the first time. The complexity of pregnancy and autoimmune conditions create therapeutic challenges that need to be considered in SLE patients with pregnancy, osteoporosis, and severe thrombocytopenia.
Is It Obesity or Metabolic Syndrome Which Has a Greater Prevalence ToCause Muscoloskeletal Complaints? A Cross Sectional Study in theCepokomulyo District, Malang Regency Perdana Aditya Rahman
Indonesian Journal of Rheumatology Vol. 16 No. 2 (2024): IJR VOL 16 No 2
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v16i2.50

Abstract

Introduction: Musculoskeletal (MSK) complaints including pain,swelling, stiffness, or immobility of joints and muscles are among themost common health issues that biomechanical factors are one of therisk factors. Metabolic syndrome is a combination of several riskfactors including obesity, hypertension, low HDL-C levels,hypertriglyceridemia, and impaired glucose tolerance. These issues areknown to influence the incidence of metabolic inflammation associatedwith several MSK diseases, in which obesity is one of the mainbiomechanical factors. Aim: To compare the Prevalence Odd Ratio(POR) of MSK complaints associated with metabolic syndrome (MetS)and obesity. Conclusion: This study included 260 patients, with 49.6%(n=129) of them having metabolic syndrome. The most common MSKcomplaint region was the right knee (n=85). MSK complaints were mostcommon in the group of patients with MetS and obesity (n=109),compared to the group with MetS or obesity alone. Prevalence OddRatio (POR) results show that Group III (group of patients with obesityand without MetS) has the highest prevalence of MSK complaints whencompared to the other three groups.
Pathogenesis, Clinical Presentations and Diagnosis of IgG4-related Disease: AReview Perdana Aditya Rahman
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): VOL 13 NO 2 2021
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v13i2.189

Abstract

IgG4-Related Disease (IgG4RD) was identified by the International Classification ofDiseases (ICD) in 2012. Numerous diseases, including Mikulicz’s disease, Kuttner’stumor, Riedel’s thyroiditis, and Ormond’s disease, are pathologically associatedwith IgG4. Here, we present a review of the clinical presentation and pathogenesisof IgG4-associated disease. IgG4-RD term has been used to refer to a group ofdiseases involving multiple organs in which there is an abundant IgG4-positivelymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and mildto moderate tissue eosinophilia, all of which show clinically as a tumefactive lesion,usually in more than one organ. IgG4 exhibits a unique property called an unstabledisulfide bond between its heavy chain, as described by Fab-arm exchange whichenables the recombination of a single IgG4 heavy chain with other IgG4 heavychains, resulting in a bispecific antibody incapable of cross-linking and thus offorming an immune complex. IgG4-RD pathomechanism that causes serum IgG4increase and tissue IgG4-plasma-cell deposition that is pathogenic, rather than theIgG4 itself. Genetic predisposition, autoimmunity, T-cell dysregulation, infection,and dysbiosis are just a few of the underlying pathomechanisms. Clinicalsymptoms are also frequently complex and may involve many organs. Confirmationof a diagnosis required a comprehensive anamnesis and examination. 
Co-Authors Yosefin Ratnaningtyas