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All Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Dian Anindita Lubis
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Correlation between Apolipoprotein B Level and Inflammatory Markers in Obese Dian Anindita Lubis; Dharma Lindarto
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 1 No. 1 (2019): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.559 KB) | DOI: 10.32734/jetromi.v1i1.1267

Abstract

Apolipoprotein B (ApoB) levels reflect the total number potentially atherogenic particles that can predict cardiovascular risk. The purpose of this study was to assess if the ApoB in obese subjects is associated with inflammatory markers. This cross-sectional study was conducted on 80 obese patients at H. Adam Malik Hospital, Medan, Indonesia. Results: Of the 80 patients studied, the average age was 38.95 + 8.13 years old. There was a strong positive correlation between ApoB and triglycerides (r=0.44, p<0.001), low-density lipoprotein cholesterol (r=0.74, p<0.001), and HOMA-IR (r=0.31, p=0.005), however not with the inflammatory markers; adiponectin (r=-0.23, p=0.41) and Chemerin (r=0.021, p=0.851). In obesity, ApoB significantly associated with lipid and insulin resistance, as a risk factor for cardiovascular disease.
Correlation Between Duration Of Protease Inhibitor Therapy With Insulin Resistance In HIV Patients Nasution, M. Arif Habibi; Nasution, Melati Silvanni; Dian Anindita Lubis
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 2 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (701.841 KB) | DOI: 10.32734/jetromi.v2i2.3875

Abstract

Abstract Metabolic diseases related to Human Immunodeficiency Virus (HIV) caused an increase in the workload of health services. Prevalence of HIV infection in Indonesian provinces varied considerably, ranging from less than 0.1% to 4%. Several studies have analyzed the correlation between insulin resistance and the usage of antiretroviral drugs, especially protease inhibitors. The main mechanism that responsible for insulin resistance is related to glucose transporter inhibition (GLUT4). This study objective is to assess the correlation between prolonged administration of protease inhibitors and insulin resistance in patients with that have diagnosed with HIV. Method. This research is an observational research using a cross-sectional design. The study was carried at the POSYANSUS Polyclinic at H. Adam Malik General Hospital in August - December 2019. The study sample were 34 HIV-treated patients receiving protease inhibitor ARV therapy. The study was analysed using chi square. Results. The characteristics of the study subjects had the most frequent age range at the age of 34 - 49 years (54.3%), men (71.4%) and women (28.6%). The longest use of antiretroviral drugs is most in the 6-12 months group (60%). Insulin resistance number in this study was 13 people (37.1%). The average HOMA-IR value of the study subjects was 2 (0.8-16.5), fasting blood sugar levels were 86 (70-283) mg / dl, fasting insulin levels were 9.1 (4.1-79.4) (µU / ml)., urea levels of 20.88 ± 9.7 mg / dl and creatinine levels of 0.81 ± 0.15 mg / dl. There was a significant correlation between the duration of ARV treatment with insulin resistance (p = 0.018; OR 7.65) Conclusion. There is a significant correlation between the duration of ARV treatment with insulin resistance. The longer Protease Inhibitor was used, the bigger insulin resistance.
Hashitoxicosis: A Case Report Dhini Sylvana; Dharma Lindarto; Santi Syafril; Melati Silvanni Nasution; Dian Anindita Lubis; Stephen Udjung
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 1 (2025): InaJEMD Vol. 2, No. 1
Publisher : PP PERKENI

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Abstract

Hashimoto Thyroiditis with Grave’s disease/Hashitixicosis is found in some cases, snd this case repirt describes a case of a woman with Hashitoxicosis. A 27 year old woman came to polyclinic on 18th March 2024 with complain of a lump felt, fatique, constipation and weight loss two month before she had weight gain later without any treatment. She was compomentis, BP 149/90 mmHg, HR 87x/i, Wayne index 0, Billewicz score -22. TSH 93.40 mclU/mL and FT4 0.39 ng/dL, anti-TPO >1000 Iau/mL, TRAb 2.46 IU/L. Thyroid ultrasound showed toxic diffuse struma, thyroid scintigraphy revealed enlarge lobes with high and even distribution and capture of radioactivity with conclusion Toxic Diffuse Struma, and cytologic examination showed colloid goiter. Patient was diagnosed as Hashitoxicosis and has been treated with levothyroxine 100 mg once daily. This woman was diagnosed as Hashitoxicosis based on clinical features of hypothyroidism at admission to polyclinic following clinical features of hyperthyroidism initially without any treatment, with laboratory results showed hypothyroidism with the increased of antibody for Hashimoto Thyroiditis and Grave’s disease. Treatment with levothyroxine 100 mg once daily showed the decrease of TSH and normal FT4 level. We report a case of Hashitoxicosis based on clinical features of hypothyroid following hyperthyroidism initially, laboratory, thyroid ultrasound thyroid scintigraphy, and cytologic examination result. Treatment with levothyroxine showed improvement.
Co-Authors dharma Lindarto, dharma Dhini Sylvana Melati Silvanni Nasution Nasution, M. Arif Habibi Nasution, Melati Silvanni Santi Syafril Stephen Udjung