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Correlation between Helicobacter Pylori Caga Antibody Serum and Gastric Premalignant Lesions in Helicobacter Pylori Patients Monica, Clarisa; Sungkar, Taufik; Ilhamd
Journal of Society Medicine Vol. 2 No. 10 (2023): October
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i10.91

Abstract

Introduction: Helicobacter pylori (H. pylori) is a spiral-shaped, anaerobic, and gram-negative pathogenic bacteria found in the gastric mucosa that causes chronic gastritis and gastric cancer. One of the most studied H. pylori virulence factors is the CagA protein in which positive anti-CagA antibodies increase the risk of malignancy in the stomach. This research was aimed to determine the correlations between Helicobacter pylori CagA antibody serum and gastric premalignant lesions in Helicobacter pylori patients. Method: This was a cross-sectional and analytic research. The sample of this study were patients diagnosed with Helicobacter pylori at Haji Adam Malik General Hospital in Medan who corresponded the inclusion criteria. The research was conducted from January to December 2022. The sampling technique used was consecutive sampling. Selected subjects underwent endoscopy and biopsy, as well as antibody detection of CagA, then the data analysis was carried out. Results: The number of samples that included in this study were 60 people. Based on demographic characteristics, the majority of patients were women, Batak ethnic, having a normal body mass index, not having a history of alcohol consumption, and non-smokers. The majority of people with Helicobacter pylori did not have CagA antibodies. There was a significant relationship (p=0.009) between  antibody of CagA and gastric premalignant lesions, as well as the prevalence ratio is 2.6. Conclusion: There is a correlation between antibody of CagA and gastric premalignant lesions in patients with Helicobacter pylori infection.
Relationship Between BMI Degree and Non-Alcoholic Fatty Liver Disease Risk Factors Marpaung, Chairunnisa Fitri; Siregar, Gontar Alamsyah; Ilhamd
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 1 (2021): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.288 KB) | DOI: 10.32734/jetromi.v3i1.5593

Abstract

Background: Obesity is a major risk factor for cardiovascular disease, type 2 diabetes, high blood pressure, sleep apnea, psychological issues, some musculoskeletal conditions, and some cancers. The aim of the study to evaluate the correlation between BMI and risk factor of non-alcoholic fatty liver disease (NAFLD). Method: The research was conducted cross-sectionally in NAFLD patients who were treated at RSUP H Adam Malik Medan and got approval from the Ethics Commission for Health Research. Sample research is NAFLD patients who are taken in consecutive sampling that meets the criteria of inclusion and exclusion.  Body mass index (BMI) is obtained by dividing a person's weight in kilograms by their height in square meters, define obesity (OB) if BMI  >  25,  overweight  (OW) BMI  23-24.9, and normoweight (NW) BMI 18.5-22.9. Diagnose NAFLD by performing ultrasound examination, resistin and adiponectin examination with ELISA (Sandwich Immunoassay), liver function according to IFCC (International Federation of Clinical Chemistry), and albumin checked by BCG method. Result: There were 67 patients (NM=32, OW=15, OB=20) NAFLD with an average age of 42.1± 11.9 years,  Comparison of NAFLD risk factors in normoweight, overweight, and obesity, showing very significant results (all p<0.001). There is a very significant correlation between BMI and all NAFLD risk factors (all p<0.001). Conclusion: There are very significant correlates between BMI and all inflammatory factors of NAFLD.
Association between VEGF–2578 C>A Gene Polymorphism and Lifestyle in H. Pylori Positive Gastritis Patients Sinulingga, Mario Eka Paskah; Ilhamd
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 2 (2021): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (740.856 KB) | DOI: 10.32734/jetromi.v3i2.6203

Abstract

Abstract Background: The polymorphisms make the differences in virulence and pathogenicity of H. pylori, which lead to different clinical manifestations after H. pylori infection. The aim research to assess correlation between between VEGF–2578 C>A Gene Polymorphism and life style in H. Pylori (+) Gastritis Patients. Method: The design of this study is a cross sectional study of H. Pylori (+) Gastritis patients, independent variables is gene polymorphism VEGF-2578C>A and dependent variables are life style (age, gender, BMI and alcohol). Infection of H. Pylori detected 14C-UBT or rapid urease test. Examination of gene polymorphism VEGF-2578C>A by performing DNA extraction (Spin Column Method) with reagent: High Pure PCR Template through PCR procedure. Results: From 59 pasien Gastritis H. Pylori (+), there is no correlation between VEGF-2578 C>A gene polymorphism (consisting of CC, CA and AA) with lifestyle (gender, age consists of < 45 years and > 45 years, BMI consists of < 25 kg/m2 and > 25 kg/m2, alcoholic drinkers ) Conclusion: There is no correlation between VEGF–2578 C>A Gene Polymorphism and life style (age, sex, BMI and alcohol drinking) in H. Pylori (+) Gastritis Patients.