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All Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Indonesian Journal of Cancer
Ananti, Anggini T.
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENYAKIT GINJAL POLIKISTIK SIMTOMATIK: PENCITRAAN, PATOFISIOLOGI, PROGNOSIS, DAN TERAPI: SYMPTOMATIC POLYCYSTIC KIDNEY DISEASE: MANAGEMENT, PATHOPHYSIOLOGY, PROGNOSIS, AND THERAPY Ananti, Anggini T.
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 7 No. 3 (2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (842.371 KB)

Abstract

Polycystic kidney disease is a life-threatening hereditary disease and is the most common cause of end-stage renal failure (ESRD). It can be classified into two based on the cause, namely Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Autosomal Resecive Polycystic Kidney Disease (ARPKD). ADPKD is common, especially in adults, while ARPKD is more common in children. ADPKD occurs predominantly in adults, whereas ARPKD is a less common and often more severe form of polycystic kidney disease (PKD) that usually presents in the perinatal period or in early childhood. Cell biology and clinical research approaches have expanded our knowledge of the pathogenesis of ADPKD and ARPKD and revealed some mechanistic overlap between the two. Research in the understanding of the genetic and molecular pathogenesis of ADPKD and ARPKD has resulted in novel targeted therapies designed to disrupt cell signaling pathways responsible for abnormal cell proliferation, dedifferentiation, apoptosis, and fluid secretion characteristics of disease. Proper diagnosis of the type of polycystic kidney requires clinical, genetic, radiological, and pathological information.
Low Anterior Resection Syndrome (LARS) and Related Factors Variation Pattern in Indonesian Tertiary Hospital: Case-Controlled Study Jeo, Wifanto Saditya; Mazni, Yarman; Putranto, Agi Satria; Primadhani, Wendy; Ananti, Anggini T.; Yoladifa, Safira Farah
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1318

Abstract

Background: Dysfunctional bowel movement, also referred to as low anterior resection syndrome (LARS), is a regular issue correlated with rectal cancer, which significantly impacts overall wellbeing. Thisstudy intended to look for the LARS incidence in patients with colorectal cancer where rectal preservation was not possible and identify factors affecting major LARS incidence in Indonesia. Method: This study follows a case-control design. Patients with rectal cancer over 18 years old who underwent tumour removal with mesorectal excision and colorectal anastomosis at Dr. Cipto Mangunkusumo General Hospital, Indonesia, from January to March 2019. The control group includes patients of eligible age who had anal sphincter preservation, stoma closure, and fall into the No LARS or Minor LARS category. Data were collected from medical records and scored with a validated LARS questionnaire. Results: Among 40 patients included, 42.5% had major LARS. The surgical procedure of low anterior resection (LAR) was significantly associated with 31.7% of major LARS patients (p = 0.04). Preoperative radiotherapy [OR 0.1 (0.02–0.49)] and anastomosis levels [OR 0.07 (0.01–0.39)] were associated with major LARS. The ROC curve revealed an AUC of 0.77, indicating significant results with the threshold for anastomosis level was 5 cm. Biofeedback revealed group differences in resting anal and maximal squeeze pressures, indicating sphincter impairment and preoperative treatment impact LARS progression. Conclusion: Major LARS development was heightened by surgical methods, preoperative radiotherapy, and lower anastomotic levels, emphasizing the role of sphincter dysfunction and preoperative interventions in LARS development.
Co-Authors Agi Satria Putranto Jeo, Wifanto Saditya Mazni, Yarman Primadhani, Wendy Yoladifa, Safira Farah