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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Archives of The Medicine and Case Reports
Fadel Fikri Suharto
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Identifikasi Polimorfisme Glu298Asp Gen eNOS pada Penderita Preeklampsia di Rumah Sakit Dr. Mohammad Hoesin Palembang Fadel Fikri Suharto; Mgs. Irsan Saleh; Subandrate Subandrate
JURNAL KEDOKTERAN DAN KESEHATAN Vol 1, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Preeklampsia adalah timbulnya hipertensi disertai dengan proteinuria pada umur kehamilan lebih dari 20 minggu atau segera setelah persalinan. Insiden preeklampsia sangat dipengaruhi oleh paritas, ras, etnis, predisposisi lingkungan dan genetik. Salah satu predisposisi genetik yang berperan memicu preeklampsia adalah kelainan gen endothelial nitric oxide synthase (eNOS) yang mengatur aktivasi nitric oxide. Polimorfisme gen eNOS dapat menurunkan aktivitas nitric oxide sehingga meningkatkan kerentanan terjadinya gangguan endothelial yang berdampak kepada  kenaikan tekanan darah dan timbul proteinuria. Penelitian ini bertujuan untuk mengidentifikasi polimorfisme Glu298Asp gen eNOS pada penderita preeklampsia di Rumah Sakit dr. Mohammad Hoesin Palembang.Penelitian ini merupakan penelitian deskriptif observasional terhadap 32 penderita preeklampsia di Rumah Sakit dr. Mohammad Hoesin Palembang. Identifikasi polimorfisme Glu298Asp gen eNOS dilakukan dengan teknik PCR-RFLP (Restriction Fragment Length Polymorphism) menggunakan enzim DpnII.Genotip GG (wild type) ditemukan sebanyak 20 subjek (62,5%), genotip GT (heterozigot mutan) sebanyak 11 subjek (34,3%), dan genotip TT (homozigot mutan) sebanyak 1 subjek (3,1%). Terdapat 51 (79,7%) alotip G (wild type) dan 13 (20,3%) alotip T (polimorfik) dari 32 subjek penelitian. Gambaran genotip dan alotip wild type lebih banyak ditemukan pada penderita preeklampsia di Rumah Sakit Dr. Mohammad Hoesin Palembang.
When the Lungs Suffer for the Ovary: A Case of Meigs Syndrome Presenting as Severe Dyspnea and Massive Unilateral Pleural Effusion Nadila Ayu Putri; Fadel Fikri Suharto
Archives of The Medicine and Case Reports Vol. 6 No. 4 (2025): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v6i4.808

Abstract

Meigs syndrome is a rare clinical entity defined by the triad of a benign ovarian tumor, ascites, and pleural effusion. It characteristically resolves completely after the surgical removal of the primary tumor. Despite its benign nature, the clinical presentation often mimics advanced-stage ovarian malignancy, posing a significant diagnostic challenge. A 47-year-old nulligravid woman presented with a two-week history of severe dyspnea, orthopnea, and pleuritic chest pain, set against a four-month backdrop of progressive abdominal distension and a 10-kg weight loss. Physical examination revealed findings consistent with a massive right-sided pleural effusion, significant ascites, and a large, firm pelvic-abdominal mass. Imaging confirmed a massive right pleural effusion and a complex ovarian mass exceeding 16 cm. A diagnosis of Meigs syndrome was established after pleural fluid analysis revealed a cytologically negative, exudative fluid. The patient's acute respiratory distress was managed with serial therapeutic thoracentesis, with 5,000 mL of fluid removed over five days, leading to dramatic symptomatic improvement. She was subsequently stabilized for definitive surgical intervention. In conclusion, this case powerfully illustrates the critical importance of including Meigs syndrome in the differential diagnosis for women with an ovarian mass and concurrent pleuro-peritoneal effusions. Timely recognition and a staged, multidisciplinary management approach are paramount for alleviating life-threatening symptoms and achieving an excellent prognosis, reaffirming the clinician's highest duty: to diligently seek out the curable, even when faced with the seemingly incurable.
Co-Authors Mgs. Irsan Saleh Nadila Ayu Putri Subandrate