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All Journal Majalah Patologi Indonesia Journal of General Procedural Dermatology and Venereology Indonesia
Riesye Arisanty
Faculty of Medicine University of Indonesia/ Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology Public Health

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The epidemiology of skin cancer at Dr. Cipto Mangunkusumo National Central General Hospital from 2014 to 2017 Wibawa, Larisa Paramitha; Andardewi, Melody Febriana; Kristanti, Inge Adi; Arisanty, Riesye
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Background: The incidence of skin cancer has been increasing over the past decades globally. At present, there is no valid national cancer data in Indonesia. The purpose of this study is to evaluate the increment of skin cancer cases at Dr. Cipto Mangunkusumo National General Hospital, Jakarta. Methods: In this retrospective descriptive study, we evaluated all pigmented skin tumor cases from June 2014 to June 2017. Data were obtained from the Department of Anatomical Pathology and medical records at Dr. Cipto Mangunkusumo National General Hospital. Data were compared with previous reports. Results: From 263 skin cancer cases, the most frequent skin cancer was basal cell carcinoma (BCC; 66.9%), followed by squamous cell carcinoma (SCC; 27.4%), and malignant melanoma (MM; 5.7%). Most of the skin cancer were predominantly in the female population. In BCC and SCC, most of the patients were within the age group above 60 years (n = 106 and 18, respectively). In MM, the incidence is greater in age group of 41–50 years (n = 5). For BCC and SCC, the distribution sites of lesions were mostly in sun-exposed areas, whereas the distribution sites of MM were mostly in non-sun-exposed areas. Median diameters of BCC, SCC, and MM were 2, 4, and 6.5 cm, respectively. There was an increase of BCC incidence from 1996 to 2017. Conclusion: In comparison with other types, the incidence of BCC in Dr. Cipto Mangunkusumo National General Hospital is increasing. A well-documented skin cancer registry is required to establish national data of skin cancer in Indonesia.
Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues Sirait, Sondang P.; Rihatmadja, Rahadi; Prayogo, Rizky Lendl; Arisanty, Riesye; Melviana, Gisca; Ohara, Kuniaki
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

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Introduction: Despite its rarity, nail involvement in Langerhans cell histiocytosis (LCH) may show various clinical presentations. This study aims to show the roles of nail involvement in LCH patients as the diagnostic and prognostic clues.Case illustrations: We presented four cases of multisystem LCH in children which were already confirmed by skin biopsy with various nail abnormalities. We were able to perform nail biopsy in two patients and confirmed the nail involvement. Histopathological examination showed the infiltration of Langerhans cells characterized by indented/reniform nuclei and CD1a expressions. All patients had high-risk organ involvements. Discussion: Langerhans cells may infiltrate the nail bed, proximal nail fold, and nail matrix. Further infiltration may destruct the nail plate. Hypothetically, we suggest that the nail bed as the initial infiltration site of Langerhans cells. The different sites of involvement lead to different clinical presentation. Nail abnormalities may predict a poorer prognosis, as they mostly occur in patients with multisystem disease. Conclusions: Nails should be routinely inspected in the suspicion of LCH. The presence of nail abnormalities in LCH patients may predict a poorer prognosis.
Clinicopathological Characteristics of Cutaneous Melanocytic Lesions for Predicting Biological Behavior: 5 Years Retrospective Study in National Referral Hospital Rosari, Bayu Perkasa; Arisanty, Riesye
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.648

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Background Cutaneous melanocytic lesions have variety of subtypes ranging from benign (nevus) to malignant lesions (malignant melanoma). Differentiating benign and malignant melanocytic lesions is challening, particularly due to overlapping characteristics. This study was conducted to determine clinicopathological characteristics of cutaneous melanocytic lesions and the prevalence ratio of each characteristic for predicting malignant behavior. Method Cross-sectional study was conducted with data retrieved from Anatomic Pathology Department of Faculty of Medicine Universitas Indonesia and Dr. Cipto Mangunkusumo Hospital. Data of 145 histopathology-confirmed cutaneous melanocytic lesions cases between 2018 – 2022 were sampled and collected. Bivariate analysis was used to determine the prevalence ratio of each characteristic to predict malignant behavior. Result Out of 145 cases, 14.5% were malignant lesions (melanoma) and the rest were benign (nevus). Clinicopathology features and characteristics were correlated with malignant behavior, such as cytological atypia (p <0.01), dermal mitosis (PR=91.5; p<0.01), asymmetry (PR=31.8; p <0.01), suprabasal melanocyte (PR=21.4; p <0.01), lower extremity location (PR=6.5; p <0.01), sized >6 mm (PR=5.2; p <0.01), and male gender (PR=3.3; p <0.01). Conclusion Clinicopathological characteristics of cutaneous melanocytic lesions such as cytological atypia, dermal mitosis, asymmetry, suprabasal melanocyte, lower extremity location, sized >6 mm, dermal lymphocytic infiltrate, and male gender were predictive to predict malignant lesions.
Hubungan antara Ekspresi Protein P16 dan Ki67 dengan Faktor Prognostik Histopatologik Melanoma Malignum Kulit Jenis Nodular Arisanty, Riesye; Tanurahardja, Budiana; Kanoko, Mpu
Majalah Patologi Indonesia Vol. 22 No. 2, Mei 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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ABSTRAK Latar belakang Pemahaman mengenai karakteristik biologik dan faktor prognostik melanoma malignum yang merupakan tumor ganas melanositik merupakan hal yang penting karena berhubungan dengan pemilihan terapi serta kesintasan penderita. Agresivitas tumor dapat dinilai dari beberapa faktor histopatologik, antara lain: adanya ulserasi, aktivitas mitosis, dan keterlibatan kelenjar getah bening. Protein p16 dan ki67 merupakan yang memiliki peran dalam prediktif prognostik melanoma malignum.Penelitian ini bertujuan mengetahui hubungan antara ekspresi protein p16 dan Ki67 pada beberapa faktor prognostik histopatologik yang dapat digunakan sebagai penanda agresivitas tumor yaitu ulserasi, aktivitas mitosis dan metastasis pada tumor primer melanoma malignum jenis nodular. Metode Penelitian ini merupakan studi potong lintang dengan metode imunohistokimia menggunakan p16 dan Ki67 pada 25 kasus melanoma malignum jenis nodular. Hasil Ekspresi protein p16 negatif ditemukan pada 40% kasus melanoma ulseratif, 52% kasus dengan aktivitas mitosis tinggi, dan 16% kasus pada metastasis kelenjar getah bening (KGB). Ekspresi Ki67 positif pada 44% kasus melanoma dengan aktivitas mitosis tinggi, dan 20% kasus melanoma metastasis serta 32% kasus dengan ulserasi. Kesimpulan Pada melanoma malignum kulit jenis noduler tidak ditemukan hubungan antara ekspresi p16 dan Ki67 dengan gambaran ulserasi, aktivitas mitosis, dan metastasis KGB. Kata kunci: aktivitas mitosis, faktor prognostik histopatologik, Ki67, melanoma malignum, melanoma nodular kutaneus, p16. ABSTRACT Background To understanding about biological behaviour and prognostic factor of melanoma malignum as a malignant tumor from melanocyte was important, because its relationship with choise of therapy and survival of the patiens. The aggresivity of the tumour, can be predicted from several prognostic factors such as: ulceration of the tumour, mitotic activity, and lymph nodes metastasis. P16 and Ki67 protein expressions can be used as a prognostic markers in cutaneous nodular melanoma malignum. Aim Assesing p16 and Ki67 protein expression and its relatinoship with several histopatological prognostic factors as a marker of aggressiveness of the tumors: ulceration, mitotic activity, and lymph nodes metastasis in cutaneous nodular melanoma malignum. Methods This was a cross-sectional study on 25 cases of nodular melanoma, stained with p16 and Ki67 antibody with immunohistochemical methods. Results P16 negative expression can be found in 40% of ulcerated melanoma cases, and 52% cases with high mitotic activity and 16% of cutaneous nodular melanoma with lymph nodes metastasis. Ki67 positive expression was found in 44% of cases with high mitotic activity, 20% cases of metastasis melanoma and 32% cases in ulcerated melanoma. Conclusion There was no statistically significant association between p16 and Ki67 expression with ulcerated melanoma, mitotic activity, and metastatic melanoma in lymph nodes. Key words: cutaneous nodular melanoma, histopathologic prognostic factors, Ki67, malignant melanoma, mitotic activity, p16.
Co-Authors Andardewi, Melody Febriana Budiana Tanurahardja Kristanti, Inge Adi Melviana, Gisca Mpu Kanoko Ohara, Kuniaki Prayogo, Rizky Lendl Rahadi Rihatmadja Rosari, Bayu Perkasa Sirait, Sondang Panjaitan Tiara Aninditha