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All Journal Indian Journal of Forensic Medicine & Toxicology
Fleur Fathi Abdel Moneim
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Public Health

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The Possible Effect of Celastrol on Ameliorating Mitochondrial Dysfunction and Neuro-inflammation in Sodium Valproate Induced- Rat Model of Autism AmlAlaa El-Din El-Sayed Ahmed; Samia HussienAbou El-Seoud; Fleur Fathi Abdel Moneim; Rasha Osama El-Esawy
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17920

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disease with impairment in social interactions,language and repetitive stereotypical behaviors. Celastrol is a natural safe compound that has antiinflammatoryand as a neuroprotective effects. 48 male offspringswistar rats divided into 6 groups;normal control group, offsprings receive vehicle, autistic offsprings receive vehicle, autistic offspringsreceive risperidone, autistic offspringsreceive celastrol, autistic offspringsreceive both risperidone&celastrol. At the end of experiment behavioral tests were performed then neurochemical analysisand histopathological examination. The obtained data showed that celastrol improved social deficits,decreased repetitive/restricted behaviors in T-maze test, significant increase in SIRT-1, GSH levelwith significant decrease in DRP-1, IL-6, caspase-3 and MDA with amelioration of histopathologicalfindings in VPA-induced ASD in both cerebellum and hippocampus. These findings pave the way forusing celastrol as an adjuvant therapy during long-term clinical use of risperidone in ASD.
Co-Authors AmlAlaa El-Din El-Sayed Ahmed Rasha Osama El-Esawy Samia HussienAbou El-Seoud