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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Erick C. Asmara
Faculty of Medicine University of Padjadjaran
Health Professions Medicine & Pharmacology Public Health

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The Estrogen Receptor Concentration and Col3A1 Gene Immunoexpression in Uterosacral Ligament is Correlated with Postmenopausal Uterine Prolapse Asmara, Erick C.
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.518 KB)

Abstract

Objective: To analyze correlation between concentration of estrogen receptor and imunoexpression of Col3A1 gene on uterosacral ligament of postmenopausal uterine prolapse patient. Methods: This is a cross-sectional analytic observational study involving 32 subjects who met inclusion criteria. Samples are taken consecutively in Dr. Hasan Sadikin Hospital in January 1st - December 31st 2012. Statistical analysis was performed with non-parametric Mann-Whitney test and Spearman’s rho non-parametric correlation test. Result: There is no significant difference of estrogen receptor concentration between postmenopausal women with and without uterine prolapse (p = 0.377), while there is no significant difference of Col3A1 gene immunoexpression between postmenopausal women with and without uterine prolapse (p = 0.119) either. There is a significant positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients (p = 0.002, r= 0.711). Conclusion: There is a positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients. [Indones J Obstet Gynecol 2013; 37-2: 103-6] Keywords: Col3A1 gene, estrogen receptor, menopause, uterine prolapse, uterosacral ligamen
The Estrogen Receptor Concentration and Col3A1 Gene Immunoexpression in Uterosacral Ligament is Correlated with Postmenopausal Uterine Prolapse Asmara, Erick C.
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.518 KB)

Abstract

Objective: To analyze correlation between concentration of estrogen receptor and imunoexpression of Col3A1 gene on uterosacral ligament of postmenopausal uterine prolapse patient. Methods: This is a cross-sectional analytic observational study involving 32 subjects who met inclusion criteria. Samples are taken consecutively in Dr. Hasan Sadikin Hospital in January 1st - December 31st 2012. Statistical analysis was performed with non-parametric Mann-Whitney test and Spearman’s rho non-parametric correlation test. Result: There is no significant difference of estrogen receptor concentration between postmenopausal women with and without uterine prolapse (p = 0.377), while there is no significant difference of Col3A1 gene immunoexpression between postmenopausal women with and without uterine prolapse (p = 0.119) either. There is a significant positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients (p = 0.002, r= 0.711). Conclusion: There is a positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients. [Indones J Obstet Gynecol 2013; 37-2: 103-6] Keywords: Col3A1 gene, estrogen receptor, menopause, uterine prolapse, uterosacral ligamen
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