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All Journal Indonesian Journal of Chemistry
Kareem, Ibtihal Kadhim
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Exploring the Anticancer Activity of Gold Complex with Newly Ligand (DDIBM): Synthesis, Spectral Identification and Magnetic Susceptibility of Its Metallic Complexes Noor, Siham Sami; Kareem, Ibtihal Kadhim
Indonesian Journal of Chemistry Vol 24, No 3 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.89954

Abstract

The new heterocyclic ligand, 5-(dimethylamino)-2-(((2-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl)benzyl)imino)methyl)phenol (DDIBM), was synthesized via the condensation of p-aminobenzylamine with 4,5-diphenyl imidazole, and the resultant compound was condensed with 4-(dimethylamino)-2-hydroxybenzaldehyde. Various instrumental techniques such as mass, 1H-NMR, IR, C.H.N elemental analysis, and UV-vis spectroscopy were used to analyze a newly synthesized ligand. A novel series of complexes was prepared by complexing the ligand with Ni(II), Cu(II), Co(II), and Au(III) and characterized using some of the mentioned techniques. Flame atomic absorption spectroscopy was used to measure the metal ion percentages in the complexes. The magnetic susceptibility and molar conductivity were studied. The electronic spectral data and the magnetic measurement predict the octahedral structure of the complexes except Au(III) complex which has square planer geometry. All complexes showed electrolyte properties. This study aimed to conduct an in vitro cytotoxicity comparative study of DDIBM and its Au(III) complex on human breast cancer cells (MCF-7) and other normal cells. The Au(III) complex was found to be highly selective in targeting cancer cells without affecting normal healthy cells, compared to the ligand. Thus, this complex can be considered as a new drug for treating breast cancer cells (MCF-7), and an attempt in the future to study its effect on other types of cancer.
Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1H-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1H,5H)-dione) and Their Biological Effectiveness as Antioxidant and Anti-Cancer Hilal, Thanaa Abdul Ameer; Kareem, Ibtihal Kadhim
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95731

Abstract

A novel ligand 5-(((2-(3-(1H-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) (L1) which contains two groups of carbonyl synthesized in one pot and three-component reaction with thiobarbituric acid as starting material, and its complexes with Co(II), Ni(II), Cu(II), Zn(II) and Au(III) have been synthesized. The results of spectrophotometry, nuclear magnetic resonance of proton (H-NMR), infrared spectroscopy (FTIR), ultraviolet and visible (UV-vis) spectroscopy, X-ray diffraction (XRD), elemental analysis (CHNS) and molar conductivity measurements were used to suggest the proposed structures. These data have been utilized to propose appropriate geometric configurations for all complexes. The L1 coordinates toward the metal ions Co(II), Ni(II), Cu(II), and Zn(II), giving an octahedral geometry, while it has a square planar shape with the Au(III) ion. Scanning microscopy (FE-SEM) was used to determine the size of nanoparticles. The present investigation employs a comprehensive molecular docking analysis to assess the binding energies of anti-cancer drugs, thereby elucidating their binding affinity towards the receptor. This indicates that the [Au(L1)Cl]Cl2 complex has a strong affinity for the protein kinase (1HK7). Significant antiproliferative activity was seen in it against human breast cancer (MCF-7) and normal cell lines (MCF-10), as evidenced by the IC50 and selective indices (SI) values. This study could contribute to the development of pharmaceutical preparations.
Co-Authors Hilal, Thanaa Abdul Ameer Noor, Siham Sami