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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Borneo Journal of Pharmacy
Wahab, Mohd Shahezwan Abd
Unknown Affiliation
Materials Science & Nanotechnology Medicine & Pharmacology

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A Cross Sectional Study on Factors Associated with Disease Progression Among Breast Cancer Patients Treated with Endocrine Therapy Rani, Nurul Sahida; Wahab, Mohd Shahezwan Abd; Zulkifly, Hanis Hanum; Mohamad, Siti Hartinie
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.13316

Abstract

Endocrine therapy (ET) has shown clinical benefits for hormone receptor (HR)-positive breast cancer (BCa) patients. Following ET initiation, patients’ response to treatment is monitored by assessing disease progression (PD). The study aims to identify the factors associated with PD, 1 year after ET initiation in HR-positive BCa patients at Hospital Sultanah Nur Zahirah (HSNZ), a public hospital in Terengganu, Malaysia. Patients were identified from the Terengganu Cancer Registry. Female patients, aged ≥ 18 years old, diagnosed with HR-positive BCa during the period from 2011 - 2014, and prescribed with at least one type of ET were included and followed-up for 5 years. Electronic medical records were reviewed for socio-demographic and clinical data. PD that occurred after 1 year of ET initiation were recorded. Adherence was measured by calculating the medication possession ratio (MPR). MPR value of <0.8 indicated non-adherence to ET. Overall, 103 BCa patients were included in the study. After one year of ET initiation, 31.1% (32/103) of patients had PD. Mean MPR values (± SD) during the first, third and fifth year of ET were 0.70±0.26, 0.66±0.29 and 0.60±0.32, respectively. Late stage BCa (p=0.007), distant metastasis at diagnosis (p=0.002), MPR value of < 0.8 in the first year of treatment (p=0.003), high comorbidity and a history of complementary and alternative medicine (CAM) use (p=0.036) were associated with PD. Adherence to ET should be emphasized in BCa patients. Women should be encouraged not to delay treatment for BCa. Pharmacists and physicians should be vigilant about CAM use in BCa patients.
Determination of Osteoporosis Risk in Post-Menopausal Women Using the Malaysian Osteoporosis Screening Tool: A Pilot Study in a Community Pharmacy Latif, Athirah Ahmad; Othman, Nursyuhadah; Azlan, Saliha; Rocky, Nik Ateerah Rasheeda Mohd; Kushairi, Siti Sarah Syahirah; Shapri, Nik Aisyah Najwa Nik Mustaffa; Wahab, Mohd Shahezwan Abd
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.10798

Abstract

Osteoporosis detection remains suboptimal in Malaysia. This study aimed to evaluate the Malaysian Osteoporosis Screening Tool (MOST) and supplementation behaviours in a community pharmacy. A cross-sectional study was conducted in a private pharmacy in Temerloh, Pahang (May–August 2025). Postmenopausal women (n = 126) completed questionnaires and underwent anthropometric assessment (BMI, hip circumference). MOST scores were calculated, and group differences were analyzed using Mann–Whitney U and Kruskal–Wallis tests (p < 0.05). All participants were classified as "at risk" (MOST ≥ 4); the median score was 42.0 (IQR 12.0–42.0). Scores were significantly higher among women aged ≥60 years (p < 0.001), those with lower education (p = 0.005), and the unemployed (p = 0.005), but were unrelated to income, ethnicity, or residence. Hip circumference was ≥90 cm in 96.8% of cases, limiting its discriminatory value. Lifestyle and clinical factors, including family history, hormone therapy, steroid use, smoking, coffee intake, carbonated drinks, and calcium- and vitamin D-rich foods, were not associated with MOST scores. Supplement use included calcium (27.8%), vitamin D (35.7%), and combined calcium–vitamin D (26.2%). Calcium users had higher scores (p = 0.011); vitamin D or combined use showed no differences (p > 0.05). MOST concentrated nearly all postmenopausal women into the high-risk category, primarily reflecting age and menopausal duration. Findings support its feasibility in community pharmacies and highlight gaps in coordinated calcium–vitamin D supplementation.
Co-Authors Azlan, Saliha Kushairi, Siti Sarah Syahirah Latif, Athirah Ahmad Mohamad, Siti Hartinie Othman, Nursyuhadah Rani, Nurul Sahida Rocky, Nik Ateerah Rasheeda Mohd Shapri, Nik Aisyah Najwa Nik Mustaffa Zulkifly, Hanis Hanum