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All Journal Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia Tunas Medika Jurnal Kedokteran & Kesehatan Jurnal Kedokteran Universitas Palangka Raya
Dohong, Almerveldy Azaria
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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PERBANDINGAN PENINGKATAN KADAR KALIUM PASIEN LANSIA DENGAN HIPERTENSI YANG DITERAPI ACE-I DAN ARB DI RSUP FATMAWATI PADA TAHUN 2017-2019 Almerveldy Azaria Dohongi; Hany Yusmaini; Erna Harfiani
Jurnal Kedokteran Universitas Palangka Raya Vol 8 No 1 (2020): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.954 KB) | DOI: 10.37304/jkupr.v8i1.1493

Abstract

Hipertensi merupakan penyakit yang umum terjadi pada lansia akibat berbagai faktor. JNC-8 merekomendasikan beberapa terapi antihipertensi, salah satunya ACE-I dan ARB. Kedua antihipertensi tersebut memiliki efek samping berupa peningkatan kadar kalium, sedangkan lansia rentan terhadap gangguan keseimbangan elektrolit. Penelitian ini dilakukan untuk membandingkan peningkatan kadar kalium pasien lansia yang diterapi ACE-I dan ARB. Penelitian ini bersifat analitik observasional dengan desain cross-sectional. Sampel penelitian adalah data rekam medis yang berjumlah 72 sampel. Pasien yang menggunakan antihipertensi ARB sebesar 39 sampel dan ACE-I sebesar 33 sampel. Penelitian ini dilakukan di RSUP Fatmawati. Teknik pengambilan sampel secara consecutive sampling. Hasil penelitian ini didapatkan kadar kalium pasien lansia dengan hipertensi yang menggunakan antihipertensi ACE-I mengalami kenaikan rata – rata sebesar 0,49 mmol/L dan ARB 0,46 mmol/L dari kadar kalium awal. Hasil uji T tidak berpasangan menunjukkan bahwa tidak terdapat perbedaan yang bermakna antara peningkatan kadar kalium pada lansia (p = 0,716). Kesimpulan yang didapat pada penelitian ini tidak terdapat perbedaan yang bermakna antara peningkatan kadar kalium pasien lansia dengan hipertensi yang diterapi ACE-I dan ARB di RSUP Fatmawati pada Tahun 2017 – 2019
The Management of Placenta Previa with A History of Antepartum Hemorrhage: An Evidence-Based Case Report Ayusti Anumillah, Rusyda; Dohong, Almerveldy Azaria; Bilqis, Nurdiza; Endjun, Judi Januadi
Jurnal Kedokteran Universitas Palangka Raya Vol 10 No 1 (2022): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v10i1.4219

Abstract

Antepartum haemorrhage is an obstetrics emergency with significant perinatal and maternal morbidity and mortality rate. It occurs in 2-5% of pregnancies. As much as 30% of maternal deaths are caused by antepartum haemorrhage. The most common antepartum haemorrhage is placenta praevia. This case report reports a patient with a diagnosis of G4P2A1, 33 weeks gestation, with antepartum haemorrhage due to total placenta praevia, a live single-head presentation fetus. The patient reported that the vaginal bleeding was bright red, painless, moderate amount, and precipitated by intercourse. they noted moderate vaginal bleeding after intercourse. Ultrasound shows the placenta is located at the anterior corpus and expanded to the internal uterine ostium (OUI), maturation grade 1. The patient was hospitalized for observation and medication. The patient received dexamethasone 2 x 6 mg for two days and nifedipine 4 x 10 mg. If ultrasound still indicates total placenta praevia at 38-39 weeks of gestation, elective Sectio Caesarea (SC) will be scheduled. The occurrence of placenta praevia is closely associated with preterm birth and the incidence of postpartum haemorrhage as well as other complications. Therefore, it is crucial to see and anticipate the incidence of placenta praevia as early as possible based on evidence.
PERBANDINGAN ANTARA PEMILIHAN OHO DAN NILAI CREATININE CLEARANCE SERTA HUBUNGANNYA PADA PASIEN DM TIPE 2 DI PUSKESMAS TERARA, LOMBOK, NTB Widya Pratiwi; Almerveldy Azaria Dohong; Joshua Sebastian Pratama Sondakh; Ahda Faza Hunafa; Syifa Muzalifa Nadobudskaya; Rody Kurniawan
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 2 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i2.9449

Abstract

Pendahuluan: Kabupaten Lombok Timur menduduki peringkat teratas dalam jumlah pasien diabetes melitus tertinggi di Nusa Tenggara Barat pada tahun 2023. Diabetes mellitus (DM) merupakan penyebab utama dari gagal ginjal. Tujuan penelitian ini untuk mengetahui perbandingan antara pemilihan obat hipoglikemik oral (OHO) dan nilai creatinine clearance (CrCl) serta hubungannya pada pasien DM tipe 2. Metode: Penelitian potong lintang terhadap 66 pasien DM tipe 2 yang menjalani pengobatan OHO di Puskesmas Terara. Analisis hubungan penggunaan jenis OHO terhadap penurunan fungsi ginjal dilakukan menggunakan uji Chi-Square. Analisis lebih lanjut dilakukan untuk melihat perbedaan rerata kadar CrCl berdasarkan golongan OHO dilakukan dengan uji T-independent dan perbedaan kadar serum kreatinin dianalisis dengan uji Mann-Whitney U. Hasil: Pasien DM tipe 2 dengan jenis OHO sulfonilurea memiliki penurunan fungsi ginjal yang lebih berat (p=0,031; OR 5,143 ((IK 95%) 1,284-20,601). Selain itu, didapatkan perbedaan bermakna pada kadar serum kreatinin antara kelompok biguanid dan sulfonilurea (p=0,029). Meskipun, rerata nilai CrCl tidak berbeda secara statistik (p=0,301). Kesimpulan: Terdapat hubungan antara jenis OHO terhadap penurunan fungsi ginjal dan perbedaan bermakna kadar serum kreatinin antara kelompok biguanid dan sulfonilurea. Akan tetapi, tidak didapatkan perbedaan rerata nilai creatinine clearance (CrCl). Pemilihan jenis OHO sebaiknya tetap mempertimbangkan parameter fungsi ginjal. Kata kunci: Creatinine Clearance, Diabetes Mellitus, Obat Hipoglikemik Oral, Penurunan Fungsi Ginjal Background: The East Lombok Regency occupies the top rank in the highest number of diabetes mellitus patients in West Nusa Tenggara in 2023. Diabetes mellitus (DM) is the primary cause of kidney failure. The aim of this study is to determine the comparison between the selection of oral hypoglycemic agents (OHA) and creatinine clearance (CrCl) values and their relationship in type 2 diabetes mellitus (T2DM) patients. Method: A cross-sectional study involving 66 type 2 diabetes mellitus (T2DM) patients undergoing oral hypoglycemic agent (OHA) treatment at the Terara Health Center. The analysis of the relationship between the use of different types of OHAs and the decreased kidney function was performed using the Chi-Square test. Further analysis was carried out to see the difference in mean CrCl levels based on OHAs class using the T-independent test and differences in serum creatinine levels were analysed using the Mann-Whitney U test. Result: Type 2 diabetes mellitus (DM) patients using sulfonylurea exhibited a more pronounced decline in kidney function (p=0.031; OR 5.143 (95% CI: 1.284-20.601)). Additionally, there was a significant difference in serum creatinine levels between the biguanide and sulfonylurea groups (p=0.029). However, the mean CrCl values were not statistically different (p=0.301). Conclusions: There was an association between the type of OHAs and the decline in renal function and a significant difference in serum creatinine levels between the biguanide and sulfonylurea groups. However, there was no statistically significant difference in the mean creatinine clearance (CrCl) values. The choice of OHA type should still consider renal function parameters. Keywords: Creatinine Clearance, Diabetes Mellitus, Oral Hypoglycemic Agents, Kidney Impairment
Peran Pemeriksaan Ultrasonografi dalam Diagnosa Klinis Flexor Tenosynovitis Piogenik Supartono, Basuki; Dohong, Almerveldy Azaria; Widiyani, Khadijah Ratna; Nadia, Nadia
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i1.14961

Abstract

Pyogenic Flexor Tenosynovitis (PFT) adalah infeksi pada selubung tendon fleksor tangan. Diagnosis PFT dapat ditegakkan secara klinis apabila terdapat empat tanda kardinal Kanavel. Namun, jika tidak terdapat empat tanda tersebut, maka dianjurkan pemeriksaan penunjang berupa ultrasonografi tangan. Pada salah satu penelitian didapatkan ultrasonografi (USG) memiliki sensitivitas 94%, spesifisitas 74% dan nilai prediksi negatif 97% dalam menentukan diagnosis PFT. Penelitian ini bertujuan untuk menganlisis peran ultrasonografi berperan dalam membantu penegakkan diagnosa PFT disertai dengan penelitian-penelitian yang mendukung pernyataan tersebut. Metode penelitian yang dapat digunakan untuk mengkaji kasus Pyogenic Flexor Tenosynovitis (PFT) adalah studi kasus. Penelitian yang secara khusus mendukung peran USG sebagai pemeriksaan penunjang yang tepat untuk PFT masih sangat sedikit, sedangkan penanganan yang cepat dan tepat diperlukan untuk mendapatkan prognosis yang baik. Oleh karena itu perlu dibahas bagaimana USG memiliki peran dalam membantu diagnosa dari PFT. Hasil ditemukan memiliki sensitivitas 94%, spesifisitas 74% dan nilai prediksi negatif 97% dalam menentukan diagnosis PFT, dan pada penelitian juga menunjukkan kisaran sensitifias 94% dalam mendeteksi abnormalitas tendon di tangan serta jari-jarinya, temuan ini membantu ahli bedah menentukan pengobatan yang tepat.
Role of serum hepcidin in neonatal sepsis detection: a systematic review Citra Yulia Sari; Selia Cahyani; Pisi Nopita Wigati; ,Muhammad Sidiq; Basra Ahmad Amru; Almerveldy Azaria Dohong; Farah Elena; Masayu Amanda Ledika
Paediatrica Indonesiana Vol. 66 No. 3 (2026): May 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Neonatal sepsis is a severe, life-threatening condition and major cause of infant mortality, especially in developing nations. Diagnosing newborn sepsis presents significant challenges due to the nonspecific symptoms. While blood cultures serve as the diagnostic gold standard, they exhibit lengthy processing times and inconsistent reliability. Hepcidin, an iron-regulating hormone with antimicrobial properties, is increasingly recognized as a promising early sepsis biomarker in neonates. Objective The objective of this study is to evaluate the diagnostic performance of serum hepcidin through a systematic review of the literature. Methods Following PRISMA protocols, PubMed, ScienceDirect, SAGE Journals, ClinicalTrials.gov, and Google Scholar were systematically searched for relevant studies conducted from 2010-2025. Observational studies assessing hepcidin levels in septic neonates were examined, with emphasis on diagnostic metrics including the Area Under the Receiver Operating Characteristic Curve (AUC), sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV). Study selection and risk-of-bias assessment were conducted independently by two reviewers using the Joanna Briggs Institute criteria. Results Among 3,047 screened publications, four studies using case-control and prospective cohort designs, comprising 481 neonates, were included. Hepcidin diagnostic thresholds for septic newborns ranged between 92-105 ng/mL, with AUC values of 0.79-0.93. Sensitivity reached 100% maximum, specificity peaked at 94%, and both PPV and NPV ranged from 87-95%. Conclusion Serum hepcidin has been identified as an early biomarker for neonatal sepsis, exhibiting diagnostic accuracy. Despite these findings, further validation and methodological standardization are essential before widespread clinical adoption
Co-Authors ,Muhammad Sidiq Ahda Faza Hunafa Ayusti Anumillah, Rusyda Basra Ahmad Amru Basuki Supartono Bilqis, Nurdiza Citra Yulia Sari Endjun, Judi Januadi Erna Harfiani Farah Elena Hany Yusmaini Joshua Sebastian Pratama Sondakh Masayu Amanda Ledika Nadia Nadia Pisi Nopita Wigati Rody Kurniawan Selia Cahyani Syifa Muzalifa Nadobudskaya Widiyani, Khadijah Ratna Widya Pratiwi