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Inneke Devi Permatasari
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Medicine & Pharmacology

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PENGARUH WAKTU PROTEKSI INFUSA BIJI Persea americana Mill. TERHADAP HEPAR DAN GINJAL TIKUS TERINDUKSI KARBONTETRAKLORIDA Lydia Setiawan; Inneke Devi Permatasari; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.898 KB) | DOI: 10.24071/jpsc.0068

Abstract

Abstract: The aim of this research is to investigate the protective activity of the infusion of seed ofPersea americana Mill. (IBPA) against carbon tetrachloride-induced hepatotoxicity andnephrotoxicity in rats. Healthy rats were weighed and randomly divided into 6 groups of 5animals in each. Group 1 were treated with olive oil (2ml/kg, i.p) as negative control. Group 2received carbon tetrachloride (2 ml/kg, i.p.). Group 3 received IBPA 360.7 mg/kg once daily for 6hours (control of dose IBPA). Group 4-6 received IBPA at doses 360.7 mg/kg orally once for 1, 4and 6 hours respectively received treated carbon tetrachloride. Blood sample from all groupswas obtained by sinus orbitalis for the estimation serum transaminase and creatinine. Thepretreatment 1,4 and 6 hours of infusion of seed of Persea americana Mill. has a potent protectiveactivity upon carbon tetrachloride-induced hepatic and nephron damage in rats.Keywords: Persea americana Mill., infusion, protective, carbon tetrachloride
Co-Authors Lydia Setiawan Phebe Hendra