Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Komunitas
Karina Citra Rani
Departement of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, East Java, Indonesia
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET ATENOLOL DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN Karina Citra Rani; Nani Parfati; Jessica Wangsa Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.503 KB) | DOI: 10.24071/jpsc.00564

Abstract

Atenolol, a competitive beta (1)-selective adrenergic antagonists, has been widely used in hypertension therapy. Administration of conventional tablets of atenolol has limitation due to patient compliance in geriatric patients. Formulation of atenolol as orally disintegrating tablet (ODT) can improve the effectiveness of the drug and patient compliance in hypertension therapy. The objective of this study was to formulate orally disintegrating tablet of atenolol using sodium starch glycolate as superdisintegrant in two different concentrations (10% and 20%). Orally disintegrating tablets (ODT) of atenolol without superdisintegrant were used as a control in this study. It was found that orally disintegrating tablets (ODT) of atenolol which used 10% sodium starch glycolate have better wetting time (9.330.58 seconds), disintegration time (15.481.16 seconds), in vitro dispersion time (24.001.00 seconds), and dissolution efficiency (95.230.14 %) than orally disintegrating tablet (ODT) which used 20% sodium starch glycolate.
Co-Authors Jessica Wangsa Putri Nani Parfati