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Analisis Imunoekspresi Programmed Death Ligand 1 (PD-L1) dan Indeks Proliferasi Ki-67 pada Tumor Astrositik Difus Billy Parulian Lubis; Hasrayanti Agustina; Hermin Aminah Usman; Bethy Surjawathy Hernowo; Sri Suryanti; Ahmad Faried; Hendrikus Bolly
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundDiffuse astrocytic tumours (DAT) is a diffuse infiltrative astrocytoma tumor accompanied by molecular parameters in the form or absence ofIsocitrate Dehydrogenase (IDH) gene mutations. The DAT category without the examination of the IDH gene mutation is classified as NotOtherwise Specified (NOS). Ki-67 is a marker for DAT proliferation so that it can assess the degree of DAT. Diffuse astrocytic tumoursbehavior is influenced by proliferative ability and the presence of a tumor microenvironment. The tumor microenvironment PD-L1 factorinfluences DAT behavior and allows the development of target therapy in DAT cases. This study aimed to analyze the relationship betweenPD-L1 and Ki-67 imunoexpression in the histopathological degree of DAT.MethodsCross-sectional study of 30 paraffin blocks of DAT NOS cases from 2014-2018 in the Department of Anatomical Pathology RSUP dr. HasanSadikin, Bandung. The sample consisted of 15 cases of grade II, 7 cases of grade III and 8 cases of grade IV, carried outimmunohistochemical staining with GFAP, PD-L1 and Ki-67. Assessment of PD-L1 immunoexpression was carried out by the histoscoremethod. The Ki-67 assessment was assessed based on its distribution, which was <10% and ≥10%. PD-L1 and Ki-67 immunoexpressionwith histopathological degrees in DAT were statistically analyzed by Kolmogorof Smirnov test, however association betweenimmunoexpression of PD-L1 and Ki-67 were analyzed by chi-square test.ResultsThere was a significant relationship between PD-L1 immunoexpression and histopathological degree in DAT (p=0.005). There was asignificant relationship between Ki-67 immunoexpression and DAT histopathology degree and with PD-L1 (p=0.001 and p=0.010).ConclusionPD-L1 immunoexpression and proliferation rates affect the degree of DAT. Proliferation rate of DAT is influenced by PD-L1 so that in thisstudy, PD-L1 and Ki-67 can be used as a marker of prognosis predictors.

Analisis Karakter Klinikopatologik pada Kasus Karsinoma Payudara Subtipe Luminal A Like Andi Susanto; Birgitta Maria Dewayani,; Bethy Surjawathy Hernowo
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundMolecular subtypes of breast carcinoma, luminal A like has the best prognosis, but in the previous studies there were cases thatshowed poor clinical outcomes. This study attempted to investigate the clinicopathological characteristics in luminal A like subtypebreast carcinoma.MethodsThis study is a cross sectional study. The samples used were 67 medical records of patients with luminal A like subtype breastcarcinoma in January 2014 to June 2019 period from Hasan Sadikin Hospital, Bandung. According to estrogen receptor (ER) andprogesteron receptor (PR) expression status by adding both intensity and distribution scores, the data were divided into twosubgroups: low histoscore (<7) and high histoscore (≥7). Clinicopathological characteristics (age, TNM stage, treatment, location,histologic type, grading and metastasis) were evaluated for each subgroup.ResultsFrom 67 luminal A like subtype breast carcinoma patients, 73.13% were in the high histoscore subgroup, with higher percentage oflow grade histopathologic features (63.27%). There were no significant differences in age and TNM staging between the twosubgroups. Among 67 breast carcinoma patients, 43 were diagnosed in advanced stages. There were significant differences inlymph nodes metastasis between the two subgroups (p-value 0.013), however, there were no significant difference in metastasis toother organs.ConclusionThis study shows that 73.13% of patients with luminal A like subtype breast carcinoma have a high histoscore of hormone receptor.Low histoscore subgroups luminal A like subtype breast carcinoma will metastasize to lymph nodes.

Karakteristik Pasien Lesi Prakanker Serviks di Rumah Sakit Tersier Jawa Barat, Indonesia Akbar Maulana; Birgitta Maria Dewayani; Bethy Surjawathy Hernowo
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe incidence of cervical cancer was continues to increase even though various risk factors and prevention efforts have been made.Cervical cancer begins with the development of a precancerous lesion (Cervical Intraepithelial Neoplasia/CIN) which is an abnormalcell growth in the cervical epithelium. This study aims to see the proportion of risk factors for cervical cancer in CIN patients at Dr.Hasan Sadikin, Bandung.MethodsThis study used a cross-sectional retrospective descriptive research method using secondary data of CIN patients for the periodJanuary 2016 - December 2020 from the archives of the anatomical pathology laboratory and clinical medical records of patients inthe form of age, marriage history, total parity, age at marriage, age at menarche, usage of hormonal contraceptives, smoking habits,clinical symptoms and histopathological degrees.ResultThere were total sample 40 cases of CIN. The 41-50 year age category is the largest age range of all NIS cases (35%). The resultsof this research data were history of marriage 1x (85%), age at marriage in the range of 20-30 years (47.5%), history of menarche inthe age range 10-15 years (90%), history of multiparous (65%), used of hormonal contraceptives (52.5%), non-smoking habits(67.5%), clinical symptoms of vaginal bleeding (42.5%) and histopathological grade of CIN 1 (47.5%).ConclusionCervical precancerous lesions at RSUP Dr. Hasan Sadikin occurred between fourth and fifth decades of life with a history of beingmarried once, multiparous, married at the age of 20-30 years, menarche at the age of 10-15 years, using hormonal contraception,not smoking, complaints of vaginal bleeding and the majority of cases were CIN 1.

Karakteristik Pasien Lesi Prakanker Serviks di Rumah Sakit Tersier Jawa Barat, Indonesia Akbar Maulana; Birgitta Maria Dewayani; Bethy Surjawathy Hernowo
Majalah Patologi Indonesia Vol. 31 No. 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i2.504

BackgroundThe incidence of cervical cancer was continues to increase even though various risk factors and prevention efforts have been made.Cervical cancer begins with the development of a precancerous lesion (Cervical Intraepithelial Neoplasia/CIN) which is an abnormalcell growth in the cervical epithelium. This study aims to see the proportion of risk factors for cervical cancer in CIN patients at Dr.Hasan Sadikin, Bandung.MethodsThis study used a cross-sectional retrospective descriptive research method using secondary data of CIN patients for the periodJanuary 2016 - December 2020 from the archives of the anatomical pathology laboratory and clinical medical records of patients inthe form of age, marriage history, total parity, age at marriage, age at menarche, usage of hormonal contraceptives, smoking habits,clinical symptoms and histopathological degrees.ResultThere were total sample 40 cases of CIN. The 41-50 year age category is the largest age range of all NIS cases (35%). The resultsof this research data were history of marriage 1x (85%), age at marriage in the range of 20-30 years (47.5%), history of menarche inthe age range 10-15 years (90%), history of multiparous (65%), used of hormonal contraceptives (52.5%), non-smoking habits(67.5%), clinical symptoms of vaginal bleeding (42.5%) and histopathological grade of CIN 1 (47.5%).ConclusionCervical precancerous lesions at RSUP Dr. Hasan Sadikin occurred between fourth and fifth decades of life with a history of beingmarried once, multiparous, married at the age of 20-30 years, menarche at the age of 10-15 years, using hormonal contraception,not smoking, complaints of vaginal bleeding and the majority of cases were CIN 1.

Gambaran Klinikopatologi pada Respon Kemoterapi Neoadjuvan Triple Negative Breast Cancer di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Widya Savitri; Bethy Surjawathy Hernowo; Sri Suryanti
Majalah Patologi Indonesia Vol. 31 No. 3 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.518

BackgroundTriple Negative Breast Cancer (TNBC) accounts for 9-17% of all breast cancer diagnoses. TNBC has a high proliferation index and a poor prognosis with a higher response rate to neoadjuvant chemotherapy, but does not correlate with Overall Survival (OS) due to chemoresistence in more than 50% of TNBC. Neoadjuvant chemotherapy with anthracycline (doxorubicin) based regimens in combination with fluorouracil and cyclophosphamide (FAC) is still an option for TNBC. The aim of this study was to determine association between clinicopathological profile and response to neoajuvan chemotherapy in TNBC at Dr. Hasan Sadikin Bandung which is a referral hospital in West Java.MethodsThis study used an analytic observational method with a cross-sectional design. The research sample consisted of 40 TNBC cases from January 2017 to December 2019 at Dr. Hasan Sadikin hospital. Data obtained from medical records and archives of the Anatomical Pathology Laboratory consist of clinical response to neoadjuvant chemotherapy, age, tumor size, lymph node metastases and distant metastases, clinical stage, type of histopathology and lymphovascular vessel invasion.ResultsIn 40 cases of TNBC, 20 cases responded and 20 cases did not respond to neoadjuvant chemotherapy. In the non-response group, there were 90% of cases with histopathologic type invasive carcinoma of no special type and 75% showed invasion of lymphovascular vessels. There were no significant differences in age, tumor size, lymphovascular vessel invasion, stage, or histopathological type in the response and non-response groups.ConclusionThere is no correlation between clinicopathological features and neoadjuvant chemotherapy response in the case of Triple Negative Breast Cancer (TNBC). This can be caused by other factors including high heterogeneous tumor microenvironment (TME).

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