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All Journal Majalah Patologi Indonesia Media Dermato-Venereologica Indonesiana
David Sitinjak
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Health Professions Public Health

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Papiloma Sinonasal dan Keganasan Terkait Papiloma Sinonasal: Studi dari Pusat Rujukan Tersier di Indonesia David Sitinjak; Lisnawati Rachmadi; Yayi Dwina Billianti
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.983 KB) | DOI: 10.55816/mpi.v31i2.498

Abstract

Background Sinonasal papilloma is a benign tumor arising from Schneiderian epithelia in sinonasal mucosa. It has the propensity towards malignant transformation. This preliminary study aims to report clinicopathological aspects of sinonasal papilloma and its malignant transformation rate. Methods A descriptive, cross-sectional study was conducted in Anatomical Pathology Department, FKUI/RSCM over a period of 2014-2019) A total of 127 histologic specimens with diagnosis of sinonasal papilloma obtained from 80 cases. Results The prevalence of sinonasal papilloma among all sinonasal neoplasms is 17.6%. Inverted papilloma was the most common histologic type 91.3%, exophytic papilloma 6.3% and oncocytic papilloma 2.5%, among male (70%), age rate 50 years old. Malignant transformation of squamous cell carcinoma 12.5%, and recurrence 21.3%, nasal congestion was the most complaint 50%. Cases were usually in T3 of Krouse stage 37.5% and managed with functional sinus endoscopic surgery 51.3%. Histological parameters were grade II 54.4%, surface keratinization 17.5%, bony trabeculae 41.3%, nasal polyps 20% and dense lymphocytic infiltrates 53.8%, foam cell infiltrates 2.5%. Mild to moderate dysplasia 8.8% and severe dysplasia 18.8%. Conclusion Sinonasal papilloma was rare sinonasal benign tumor. Inverted papilloma type was local aggressive, recurrence, dysplastic and malignant transformation, among male, age 50 years old, main complaint of nasal congestion, in Krouse stage T3, and managed by Functional Sinus Endoscopy Surgery (FSES
HEMATOLOGICAL-RELATED MALIGNANCY-INDUCED EOSINOPHILIC DERMATOSIS (HE REMAINED): SEBUAH LAPORAN KASUS DERMATOSIS EOSINOFILIK TERKAIT LEUKIMIA LIMFOSITIK KRONIS Agassi Suseno Sutarjo; Danang Tri Wahyudi; Aida Sofiati Dachlan; Fadhli Aulia Mughni; Evlina Suzanna; David Sitinjak
Media Dermato-Venereologica Indonesiana Vol 50 No 2 (2023): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i2.401

Abstract

Introduction: Hematological-related malignancy-induced eosinophilic dermatosis or He Remained is a rare paraneoplastic cutaneous reaction particularly associated with various hematological malignancies. It has a vast clinical presentation ranging from papules, plaque, to blisters and bullae and resembles other dermatoses. We report a case of He Remained on patient with chronic lymphocytic leukimia on remission. Case: A 49-year-old women who had been diagnosed with chronic lymphocytic leukimia presented with a pruritic rash which had been present for a month. Histopathology examination revealed eosinophilic infiltrate and the diagnosis of He Remained was established. She was treated with systemic steroid and achieve relieve of symptoms. Discussion: The pathogenesis of the dermatosis has not been fully interpreted. The cutaneous symptoms have been found to be unrelated to the hematologic malignancy course. Histopathology studies have an important role as one of the diagnostic criteria. Various treatments have obtained some response in short term; however treatments to control the chronic and relapsing course of the disease has been lacking. Conclusion: He Remained has a negative impact for patients and remains a diagnostic and therapeutic challenge for Dermatovenereologist. This case reports hopes to raise awareness given the rarity of the dermatoses.
Co-Authors Agassi Suseno Sutarjo Aida Sofiati Dachlan Danang Tri Wahyudi EVLINA SUZANNA Fadhli Aulia Mughni Lisnawati Rachmadi Yayi Dwina Billianti