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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) Indonesian Journal of Electrical Engineering and Computer Science
Manaswini Pradhan
Fakir Mohan University
Computer Science & IT Engineering

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Evolutionary Computational Algorithm by Blending of PPCA and EP-Enhanced Supervised Classifier for Microarray Gene Expression Data Manaswini Pradhan
IAES International Journal of Artificial Intelligence (IJ-AI) Vol 7, No 2: June 2018
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.946 KB) | DOI: 10.11591/ijai.v7.i2.pp95-104

Abstract

In DNA microarray technology, gene classification is considered to be difficult because the attributes of the data, are characterized by high dimensionality and small sample size. Classification of tissue samples in such high dimensional problems is a complicated task. Furthermore, there is a high redundancy in microarray data and several genes comprise inappropriate information for accurate classification of diseases or phenotypes. Consequently, an efficient classification technique is necessary to retrieve the gene information from the microarray experimental data. In this paper, a classification technique is proposed that classifies the microarray gene expression data well. In the proposed technique, the dimensionality of the gene expression dataset is reduced by Probabilistic PCA. Then, an Artificial Neural Network (ANN) is selected as the supervised classifier and it is enhanced using Evolutionary programming (EP) technique. The enhancement of the classifier is accomplished by optimizing the dimension of the ANN. The enhanced classifier is trained using the Back Propagation (BP) algorithm and so the BP error gets minimized. The well-trained ANN has the capacity of classifying the gene expression data to the associated classes. The proposed technique is evaluated by classification performance over the cancer classes, Acute myeloid leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). The classification performance of the enhanced ANN classifier is compared over the existing ANN classifier and SVM classifier.
Lung cancer segmentation and classification using hybrid CNN-LSTM model Manaswini Pradhan; Ahmed Alkhayyat
Indonesian Journal of Electrical Engineering and Computer Science Vol 41, No 1: January 2026
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijeecs.v41.i1.pp309-319

Abstract

A collection of genetic disorders and various types of abnormalities in the metabolism lead to cancer, a fatal disease. Lung and colon cancer are found to be main causes of death and infirmity in people. When choosing the best course of treatment, the diagnosis of these tumors is usually the most important consideration. This study's main objectives are to classify lung cancer and its severity, as well as to recognize malignant lung nodules. The suggested approach additionally classifies the stages of lung cancer in order to recognize lung nodules. The convolutional neural network (CNN) is used to detect lung nodules, identifying a nodule which is accurately segmented and classified. The suggested method is separated into dual parts: primarily, it classifies normal and abnormal behavior, and the subsequent one classifies the different stages of lung cancer. Texture and intensity-based features are extracted during the classification stage. When compared to other methods such as nested long short-term memory (LSTM)+ CNN, the hybrid CNN LSTM obtains superior outcomes in terms of accuracy (99.35%), specificity (99.30%), sensitivity (99.32%), and F1-score (99.29%).
Co-Authors Ahmed Alkhayyat