Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Indian Journal of Forensic Medicine & Toxicology
Mukhallad A. Ramadhan1 ; Haider F. Al-Saedi2 ;Ghufran L. Ismaeel2 ; Uday Abdul-Reda Hussein3
Unknown Affiliation
Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
The Possible Nephroprotective Effect of Roflumilast Ameliorating Glycerol -Induced Myoglobinuric Acute Renal Injury in Rabbits Model Mukhallad A. Ramadhan1 ; Haider F. Al-Saedi2 ;Ghufran L. Ismaeel2 ; Uday Abdul-Reda Hussein3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12138

Abstract

urther leads to tissue necrosis and inflammation. While, roflumilast N-oxide is an active metabolite ofroflumilast that rising the cyclic adenosine-3?, 5?-monophosphate by inhibiting PDE4.Thirty rabbits were divided into three groups, control group was received normal saline intra-muscularly anddrived from water for eighteen hours before. Second group was received a single dose glycerol injected intramuscularly after drived from water for eighteen hours .Third group was received roflumilast intraperitonealdaily for three days after received a single dose of glycerol .All animals were sacrificed after 72 hour, and then blood collected by cardiac puncture for evaluation thechanges in the levels of renal function tests and histopathological study of rabbit’s kidneys tissues areevaluated evaluation and scoring the changes of tested agents. The numerical data are expressed as means ±standard error means and analyzed by using SPSS version 20.The results of the levels serum urea and creatinine found to be significantly reduced by roflumilast usingANOVA test. Besides, the histopathological changes showed ameliorative effects of roflumilast in comparedto glycerol group. From this study, one could be concluded the protective effect of roflumilast in case ofrenal failure induction by glycerol.
Co-Authors