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All Journal Indian Journal of Forensic Medicine & Toxicology
Al-Moghira Khairi Al-Qaysi1 ; Safaa Abed Latef Al-Meani2 ; Mushtak T.S. Al-Ouqaili3
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The Effect of Dual-Species Biofilms, Monosaccharide and D-Amino Acids on Pseudomonal Biofilm Al-Moghira Khairi Al-Qaysi1 ; Safaa Abed Latef Al-Meani2 ; Mushtak T.S. Al-Ouqaili3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13728

Abstract

Background: The major therapeutic failure in clinical settings is due to problematic biofilm-producingbacteria like Pseudomonas aeruginosa. This study aims to investigate the effect of dual-species biofilms,monosaccharide, and D-amino acids on pseudomonal biofilm. Methodology: A total of 130 patients withcatheter-associated urinary tract and wound infections were involved in this study. Quantitative biofilmassay by alginate beads was performed. The dual-species biofilms have been done, and the effect ofciprofloxacin, monosaccharides, and D-amino acids on sessile cells was detected. Conclusion: This studysuggested that the combined action of both monosaccharides (glucose and galactose) and the combination ofeach one with ciprofloxacin is the enhancing of P. aeruginosa biofilm and increases survival strategy againstciprofloxacin. In contrast, a noticeable biofilm reduction and marked synergistic action for ciprofloxacinhave been determined in the combination of the two D-amino acid, alanine, and glycine in comparison tothe effect of each one alone. Furthermore, the dual biofilm of P. aeruginosa with each of K. pneumonia andE. coli, markedly reduced pseudomonal biofilm, while co-culture with S. aureus revealed strong support ofpseudomonal pathogenicity and increased its biofilm production.
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