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Julfina Bisanto
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Health Professions Medicine & Pharmacology

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Clinical and laboratory profiles of hepatitis C in hemophiliac children Hanifah Oswari; Ferry Damardjati S.P.; Djajadiman Gatot; Zakiudin Munasir; Julfina Bisanto
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.944 KB) | DOI: 10.14238/pi47.5.2007.229-33

Abstract

Background Hepatitis C virus (HCV) infection is common in hemophiliac receiving multiple coagulation factor transfusions before the introduction of donor screening and viral inactivation techniques. Information on the clinical profiles of HCV infection in children is still limited.Objective To describe clinical and laboratory profiles of HCV infection in hemophiliac children. Methods Patients registered at the Hemophilia Society of Department of Child Health, Cipto Mangunkusumo Hospital, who had positive anti-HCV were enrolled. None of them received antiviral treatment. All subjects infected by HCV before the age of 18 years and at least had positive anti-HCV test result for 6 months underwent clinical examination, alanine aminotransferase (ALT), platelets, and HCV RNA tests.Results Thirty nine subjects were available for review, with the median age of 15 years, and the mean age of the first time getting transfusion was 15 months. Twenty two (56%) of 39 subjects showed clinical manifestations. Liver and spleen enlargement were not found in any of the subjects. Ten (26%) subjects showed elevated ALT. Platelet count was within normal limit in all subjects. Twenty four (61%) patients had chronic hepatitis, whereas the remaining 15 (39%) subjects spontaneously cleared from HCV.Conclusions Pediatric HCV infection showed mild clinical manifestations. Sixty one percent subjects developed chronic hepatitis. The abnormality of laboratory finding may be associated with the future chronic liver disease.
Profile of alanine aminotransferase and hepatic iron accumulation in thalassemic patients with or without anti-hepatitis C virus Purnamawati S P; Pamela Kartoyo; Imral Chair; Julfina Bisanto; Hanifah Oswari
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.622 KB) | DOI: 10.14238/pi44.3.2004.85-9

Abstract

Background Repeated blood transfusions in thalassemic patientscause iron accumulation in tissues and might impair organ func-tion. Other peril of blood transfusion is hepatitis C virus infection.Objectives This study aimed to find out the proportion of increasedalanine aminotransferase (ALT), increased transferrin saturation(TS), and positive anti hepatitis C virus (anti-HCV) among thalas-semic patients and to get the profile of ALT among thalassemicpatients who have increased TS and positive anti-HCV.Methods This cross-sectional descriptive study was conductedon β- and β-HbE-thalassemic patients at the Thalassemia Outpa-tient Clinic, Department of Child Health, Medical School, Univer-sity of Indonesia–Cipto Mangunkusumo Hospital in May 2002.Results Subjects were 57 homozygous β-thalassemic and 33 β-HbE-thalassemic patients. No one had regular desferoxamine orhistory of splenectomy. Proportions of increased ALT, TS, and posi-tive anti-HCV were 76%, 78%, and 6%, respectively. Duration ofillness, total volume of packed red cell (PRC) transfusions, TS level,and positive anti-HCV seemed to have role in the increased pro-portion of subjects with increased ALT, whereas duration of illnessand total volume of PRC seemed to have role in the increased TS.Conclusion Factors that seem to have a role in the increasedproportion of subjects who had increased ALT and TS were (1)duration of illness, total volume of PRC transfusion, TS, and posi-tive anti-HCV; 2) duration of illness and total volume of PRC trans-fusion, respectively
Hepatitis B serologic patterns in children of HBV carriers or infected mothers Julfina Bisanto; Imral Chair; Dyah Istikowati
Paediatrica Indonesiana Vol 44 No 5 (2004): September 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.91 KB) | DOI: 10.14238/pi44.5.2004.176-80

Abstract

Background Vertical transmission is usually the cause of increas-ing carrier rates for hepatitis B infection, especially in highly en-demic areas.Objective To determine the serologic patterns of hepatitis B inchildren of HBV carrier/infected mothers.Methods This was a cross sectional study on children of HBVcarrier/infected mothers. Subjects were recruited consecutively andexamined at the Department of Child Health, Cipto MangunkusumoHospital during January–July 2003. Children were included if theywere generally healthy and their parents gave permission. Chil-dren with chronic illness, previous blood transfusions, or drug abusewere excluded.Results Fifty-nine children of 32 HBV carrier/infected mothers wererecruited. HBsAg was positive in 8 children, anti-HBs in 37, andanti-HBc in 4 children. Seventy-three percent of children had beenvaccinated against HBV but only 81% had positive anti-HBs. Ofeighteen children who received hepatitis B vaccine and HBIg atbirth, none was infected. Six out of 25 children who received onlyhepatitis B vaccine were infected.Conclusion HBsAg, anti-HBs, and anti-HBc were positive in 14%,36%, and 7% of children of HBV carrier/infected mothers, respec-tively
Co-Authors Djajadiman Gatot Dyah Istikowati Ferry Damardjati S.P. Hanifah Oswari Imral Chair Pamela Kartoyo Purnamawati S P Zakiudin Munasir