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All Journal Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology
Fadhil Lafta Faraj
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Medicine & Pharmacology Public Health

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Anti-Cancer and Acute Toxicity Activity of Benzo[e]Indol-2- Ylidene)-3 -(4-Methoxyphenyl) Imino Propanal Ahmed Jasim Mohammed Gawi; Walaa Najm Abood; Fadhil Lafta Faraj
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14619

Abstract

Background: The new indole Schiff base compound benzo[e]indol-2-ylidene)-3-(4-methoxyphenyl)iminopropanal](2P)was investigated for antioxidant, toxicity and anti-tumor ability for A547 cell, PC3 celland WRL 68 cell.Results: 2P has antioxidant ability for IC50 (75 µg/mL) compared with control ascorbic acid (27 µg/mL).Antitumor ability to 2P for A547 cell and PC3 cell were decreased significantly after treated with 2P in dosedependent manner at 24,48 and 72 hours, while no toxicity effect on the WRL 68 cell. The antitumor effectwas through accelerated apoptosis, the alteration in nuclear morphology. Increasing in the cells membranepermeability, decreasing in the nucleus intensity with the increasing of concentration of 2P compound wasobserved.MMP is disturbed in the apoptosis by forming of permeability and the result was showed that 2P activatedrelease cytochrome c significant higher than control.2P break down the cell cycle progress in G1 phase (P<0.05) compared with control. Conclusion: this result was conducted the new 2P compound has antioxidantand antitumor ability that may be used 2P a new anticancer drug.
Synthesis and Characterizations of New Pyrazoles and Study the Toxic Effect of the Compounds in Hella and RD Cancer Cells lines Fadhil Lafta Faraj
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

New Pyrazole Derivatives have been synthesized by reaction of 2-(5-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with hydrazine and substituted phenylhydrazine. The chemical purity of the new synthesized compounds was tested by TLC and the chemical structures were characterized by, FT-IR, 1H, and APT 13C NMR. The biological activity of the new synthesized compounds was conducted to investigate the toxic effect of these compounds on the growth of tumor cells represented by the line of HeLa cell line and the human muscle cancer RD in the laboratory. The study included exposure period 24 and 48 hours, and showed good and different results. Keywords: Pyrazole Derivatives, Hydrazine and substituted phenylhydrazine, Hella and RD Cancer Cells lines.
Co-Authors Ahmed Jasim Mohammed Gawi Walaa Najm Abood