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All Journal Indian Journal of Forensic Medicine & Toxicology
Abdul-Samed Uleiwi Hassan
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Public Health

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Relationship between Blood group and Chronic Myeloid Leukemia with the Role of the Oxidative Stress Baneen Saleem Salih; Abdul-Samed Uleiwi Hassan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14674

Abstract

Chronic myeloid leukemia characterized by the expansion of a clone of hematopoietic cells that carriesthe Philadelphia chromosome (Ph). The aim of study are to find if there is an association between bloodgroups and chronic myeloid leukemia, and to determine the role of the oxidative stress as risk factor. Ninetypersons included in the study (45 as patient and 45 as control group). Patients were suffering from CML,the control are free from this disease. There are ranged from (21-60) years old where they are divided into four group according to blood group (A, B, AB, and O). The sera were collected from the 90 personsand analyzed by using enzyme linked immunosorbent assay (ELISA) for MDA and GSH. The results ofthe study show that blood group O (44%) predominates in CML patients group followed by blood group A(22%), B (18 %) and AB (16%). The mean serum level MDA value shows highly significance at (P?0.001)change in the patients group in comparison with control. Also show that the level of MDA in male (900. 99± 603.89) is significantly higher than in female (582.28 ± 562.29). The mean serum level of GSH show thatsignificant decrease at (P?0.05) in patients group (40. 12 ± 27.33) than in control groups (55.20 ± 28.79). Asa conclusion from this study, the importance of MDA and GSH in CML patients can be used to detect thecomplications related to the among these patients.
Co-Authors Baneen Saleem Salih