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All Journal Indian Journal of Forensic Medicine & Toxicology
Ayser Hameed Latif
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Public Health

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New Insight in the Using of Core Needle Biopsy As First Line in Preoperative Diagnosis of Thyroid Nodule Eaman Suud Khalifa; Ayser Hameed Latif
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14711

Abstract

Background: The diagnosis of thyroid nodule by core needle biopsy is different from post resection samplesbecause of difficulties in applying histological criteria for both samples due to limitation in core needlebiopsy sample .Objective: To assess the utility of core needle biopsy in diagnosis of thyroid nodule.Material and Method: We use core needle biopsy as first line method instead of fine needle aspirationand to reach final diagnosis after resection sample . Core needle biopsy results were divided to six groups)unsatisfactory, benign, indeterminate, follicular neoplasm, suspicious for malignancy and malignant)according to The Bethesda system for reporting thyroid cytopathology (1,2,3) .Result : A total of 45 thyroid nodules taken from 45 patients (30 female and 15 male) . Malignant changeswere seen in 19 nodules after surgery and 26 after core needle biopsy. Benign nodules were diagnosed in 11cases after surgery and in 12 cases after core needle biopsy . Final diagnoses were concluded for 34 nodules(76%). Twenty one nodules were diagnosed as malignant nodules and 13 nodules were diagnosed as benignnodules .Conclusions: Core needle biopsy is reliable and valuable tool for the diagnosis of thyroid nodule and canbeen used as an alternative to fine needle aspirate especially in patients with inconclusive results .
Evaluation of the Diagnostic Role of Gata3 Immunohistochemistry on Cytology Specimens for Metastatic Breast Carcinoma Eaman Suud Khalifa; Ayser Hameed Latif
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15560

Abstract

Objective: Distinguishing of metastatic breast carcinoma from nonmammary metastatic carcinomas by cytological examination might have some difficulties. The sensitivity of traditional tumor markers for immunostaining might be not high enough . The role of GATA3 immunohistochemistry as a novel marker of primary and metastatic stages of breast carcinoma in specimens of fine needle aspiration was evaluated.Materials and Methods: Sections were taken from 73 cases of FNA samples of metastatic malignancies including 38 metastatic breast cancer and 35 nonmammary malignancies were stained with GATA3 immunohistochemical marker. Samples of FNA were taken from pleural effusion, ascetic fluid and lymph nodes. Results: Eighty-nine percent (34/38) of metastatic breast carcinoma cases were regarded as GATA3 positive expression , while all nonmammary adenocarcinoma samples were GATA3 negative . Most of GATA3 positive samples showed intense nuclear staining in the majurity of the malignant cells.Conclusions: GATA3 staining is an important addition to immunohistochemical panels for fine needle aspiration samples for distinguishing metastatic breast carcinoma from other malignancy.
Co-Authors Eaman Suud Khalifa