<![CDATA[Background: Cholinestrase inhibitor insecticides considered one of the most common causes of morbidityand mortality due to poisoning especially in developing countries like Egypt. This work aims to studythe possible role of Creatine Phosphokinase (CPK), Amylase, Lactate Dehydrogenase (LDH), C-ReactiveProtein (CRP) and blood sugar status in predicting the severity of acute cholinesterase inhibitor insecticidespoisoning at the time of admission.Subjects and Methods: This work was done at Poison Control Center of Ain Shams University Hospitals –Egypt, and was carried on 150 patients admitted with acute (CEI) insecticides poisoning. Clinical evaluationof the patients and poisoning severity was graded according to Peradynia organophosphorus poisoning(POP) scale, then venous blood sample was collected from patients and examined for CPK, Amylase, LDH,CRP and random blood sugar (RBS).There is significant increase of CPK, LDH, CRP RBS and amylase enzyme specially with increase theseverity in those patients admitted to ICU rather than inpatient, and in mechanically ventilated patientsrather than non mechanically ventilated and in died patients rather than survivors.Conclusion: CPK, Amylase, LDH, CRP and random blood sugar could be used to predict severity ofcholinesterase inhibitor insecticides poisoning. They can also predict ICU admission, mechanical ventilationneed and mortality. Amylase is a better predictor of respiratory failure and need of mechanical ventilation.]]>
