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All Journal Indian Journal of Forensic Medicine & Toxicology
Reyadh H. Al-Mosawi
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Public Health

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Possible Effect of vitamin D3 on Follicular Maturation in Polycyctic Ovarian Syndrome (PCOS) Women Reyadh H. Al-Mosawi; Nuha Hamood; Huda Salim Altaee
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14844

Abstract

Polycystic ovarian syndrome (PCOS) is the most common reproductive age endocrine condition in women.Most likely, one of the major problems of PCOS patients are vitamin D3 deficiency. Therefore, investigationof the association between vitamin D3 deficiency and ovulation in PCOS women patients might help toexplore the possible relationship between them. Sixty-six patients were recruited from a private clinic inKarbala city / Al-Hindiya district, Iraq. The patients were divided into two groups (33 patients each), thefirst group treated with metformin 850 mg, b.i.d, and placebo. The second group treated with metformin 850mg, b.i.d and vitamin D3 oral supplementation 5000 IU/day for 3 months. Ultrasonography was performedmonthly on day 13 to assess the follicular size. D3 blood level was measured at the end of the 3 months.The present study demonstrated that daily D3 5000IU in PCOS women with deficient D3 whom already onscheduled metformin 850 mg b.i.d for 3 months significantly (p<0.05) increased the mid-cycle follicularsize by one 3rd in comparison to placebo group. The important finding was that vitamin D3 might enhancefollicular maturation in PCOS patients.
Co-Authors Huda Salim Altaee Nuha Hamood