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All Journal HAYATI Journal of Biosciences Jurnal Veteriner
Ans Budi Hartanta
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Veterinary

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The Effect of Seaweed Eucheuma cottonii on Superoxide Dismutase (SOD) Liver of Hypercholesterolemic Rats TUTIK WRESDIYATI; ANS BUDI HARTANTA; MADE ASTAWAN
HAYATI Journal of Biosciences Vol. 15 No. 3 (2008): September 2008
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.924 KB) | DOI: 10.4308/hjb.15.3.105

Abstract

Intracellular antioxidant superoxide dismutase (SOD) was reported decreased in the liver and kidney of hypercholesterolemic rats. This study was conducted to observe the effect of seaweed Eucheuma cottonii powder on the profile of blood cholesterol and the level of SOD in liver tissues of hypercholesterolemic rats by using immunohistochemical technique. Twenty male Wistar rats were used for this study. Those rats were divided into four groups; (i) negative control group (A), (ii) hypercholesterolemia group treated by 5% seaweed powder (B), (iii) hypercholesterolemia group treated by 10% seaweed powder (C), and (iv) Positive control group or hypercholesterolemia group (D). The experiment was carried out for 35 days. Hypercholesterolemia condition (> 130 mg/dl), except group A, was achieved by feeding the rats with commercial diet containing 1% cholesterol. Drinking water was given ad libitum for 40 days. The results showed that seaweed powder decreased the total cholesterol, low density lipoprotein (LDL), triglyceride, and increased the level of high density lipoprotein (HDL) and SOD status in the liver tissues of hypercholesterolemic rats. The treatment of 10% seaweed powder gave better results than that of 5%. These results suggested that dietary fiber such in the seaweed powder has antioxidant activity. Key words: superoxide dismutase (SOD), seaweed-Eucheuma cottonii, hypercholesterolemia, liver, immunohistochemistry
Tepung Rumput Laut (Eucheuma Cottonii) Menaikkan Level Superoksida Dismutase (Sod) Ginjal Tikus Hiperkolesterolemia Tutik Wresdiyati; Ans Budi Hartanta; Made Astawan
Jurnal Veteriner Vol 12, No 2 (2011)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.497 KB)

Abstract

Hypercholesterolemia condition was reported can decrease activities of antioxidant superoxidedismutase, catalase, and glutathione peroxide. This study was conducted to observe the role of seaweed(Eucheuma cottonii) powder in increasing the level of antioxidant cooper, zinc-superoxide dismutase (Cu,Zn-SOD) in kidney tissues of hypercholesterolemic rats. Twenty male Wistar rats were used in this study.Those rats were divided into four groups ; (1) Negative control group (A), (2) and (3) werehypercholesterolemic groups that were treated with 5% (B), and 10% (C) of seaweed powder, and (4)Hypercholesterolemic group as positive control (D). The treatment was carried out for 35 days.Hypercholesterolemia condition (>130 mg/dl), except for group A, was achieved by feeding the rat withcommercial diet containing 1% cholesterol and drinking water ad libitum for 40 days. Serum total cholesterolwas analyzed both before and after treatment. Rat kidneys were taken at the end of treatment, andprocessed by using paraffin embedding standard method. The tissues were then stained usingimmunohistochemical technique to Cu,Zn-SOD. The results showed the seaweed powder decreased serumtotal cholesterol, increased caecum cholesterol, repaired alteration of kidney tissues, and increased thelevel of antioxidant Cu,Zn-SOD in the kidney of hypercholesterolemic rats. Dietary fibers and antioxidantactivity of 10% seaweed powder was better than the of 5%.
Co-Authors MADE ASTAWAN Tutik Wresdiyati