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All Journal Indian Journal of Forensic Medicine & Toxicology
Gatha Mohanty
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Hypersensitivity- An Update Mohit Das; Abhaya Chandra Das; Sourav Panda; Rashmita Nayak; Rinkee Mohanty; Gatha Mohanty
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14976

Abstract

Dentinal hypersensitivity (DHS) can be defines as a short sharp pain that occurs as a response to variousstimuli on exposure of dentinal tubules to the external environment and which cannot be described as anyother disease. The most important part of the treatment is to identify the etiology behind the sensitivity andtreating the condition accordingly. Differential diagnosis may include pulpitis, carious teeth, chipped tooth,cracked tooth syndrome etc. The treatment modalities depend upon whether the sensitivity is due to gingivalrecession, tooth wear lesion or periodontitis or related causes. This review highlights various strategies tocounter this disease as well discusses various desensitizing agents recently in use like Novamin, Biomin,Calcium phosphate dentifrices, Nanoparticles and herbal desensitizing agents.
Role of PRGF (Plasma Rich in Growth Factors) in Periodontal Regeneration Mohit Das; Abhaya Chandra Das; Sourav Panda; Manoj Kumar; Rinkee Mohanty; Gatha Mohanty
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14979

Abstract

Platelet-rich-growth-factors (PRGF), a modification of fibrin glue made from autologous blood, is beingused to deliver growth factors in high concentration to sites requiring osseous grafting. Growth factorsreleased from the platelets include platelet-derived growth factor(PDGF), transforming growth factor-beta(TGF-ß), platelet-derived epidermal growth factor (PDGF), platelet-derived angiogenesis factor, insulin-likegrowth factor 1(IGF1), and platelet factor 4. These factors signal the local mesenchymal and epithelial cellsto migrate, divide, and increase collagen and matrix synthesis. Anitua et al in 2001 introduced the concept ofPRGF and since then it has been used for a variety of purposes in the field of dentistry and oral implantologyfor proper wound healing and regeneration of periodontal tissues. This review aims to give a brief ideaabout the various uses of PRGF and the possibility of utilization in the future taking into consideration manystudies that have been done. The main advantage of using PRGF is that it lacks the leukocyte content thuspreventing damage to the tissues during healing due to the acid hydrolases and proteases released from theneutrophils. It has been previously used for treating intrabony defects, to increase the implant-bone contactarea, for recession coverage etc. In other fields of medicine, it has been used to cure osteoarthritis, to treatchronic ulcers as well. Therefore, PRGF is a very effective blood concentrate with a high concentration ofgrowth factors and its use should be increased in the clinical practice.
Co-Authors Abhaya Chandra Das Manoj Kumar Mohit Das Rashmita Nayak Rinkee Mohanty Sourav Panda