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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indian Journal of Forensic Medicine & Toxicology
Manoj Kumar
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Agriculture, Biological Sciences & Forestry Environmental Science Public Health

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Role of PRGF (Plasma Rich in Growth Factors) in Periodontal Regeneration Mohit Das; Abhaya Chandra Das; Sourav Panda; Manoj Kumar; Rinkee Mohanty; Gatha Mohanty
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14979

Abstract

Platelet-rich-growth-factors (PRGF), a modification of fibrin glue made from autologous blood, is beingused to deliver growth factors in high concentration to sites requiring osseous grafting. Growth factorsreleased from the platelets include platelet-derived growth factor(PDGF), transforming growth factor-beta(TGF-ß), platelet-derived epidermal growth factor (PDGF), platelet-derived angiogenesis factor, insulin-likegrowth factor 1(IGF1), and platelet factor 4. These factors signal the local mesenchymal and epithelial cellsto migrate, divide, and increase collagen and matrix synthesis. Anitua et al in 2001 introduced the concept ofPRGF and since then it has been used for a variety of purposes in the field of dentistry and oral implantologyfor proper wound healing and regeneration of periodontal tissues. This review aims to give a brief ideaabout the various uses of PRGF and the possibility of utilization in the future taking into consideration manystudies that have been done. The main advantage of using PRGF is that it lacks the leukocyte content thuspreventing damage to the tissues during healing due to the acid hydrolases and proteases released from theneutrophils. It has been previously used for treating intrabony defects, to increase the implant-bone contactarea, for recession coverage etc. In other fields of medicine, it has been used to cure osteoarthritis, to treatchronic ulcers as well. Therefore, PRGF is a very effective blood concentrate with a high concentration ofgrowth factors and its use should be increased in the clinical practice.
Nutritional, Hypoglycemic, and Haematinic Potentiality of Edible Mushroom Pleurotus tuber-regium (Rumph. ex Fr.) Singer Sukumar Dandapat; Manoj Kumar; Rakesh Ranjan; Manoranjan Prasad Sinha
Journal of Tropical Life Science Vol. 9 No. 2 (2019)
Publisher : Journal of Tropical Life Science

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Abstract

Mycochemical composition, calorific value, the antioxidant activity of Pleurotus tuber- regium was analyzed and impact of P. tuber- regium extract on rat model especially glycemic, vitamins and blood parameters were explored to validate its medicinal importance. Mycochemical screening showed the presence of biochemicals such as phenols, flavonoids, proteins, carbohydrates etc. The extract showed good antioxidant activity (33.62% total antioxidant activity equivalent to 21.30 µg ascorbic acid). The extract showed dose -dependent hypoglycaemic activity by significant decreased average blood glucose level at high dose (100.62 ± 1.04mg/dL) compare to control (124.40 ± 1.45 mg/dL), haematinic activity by elevation of hemoglobin (14.75 ± 0.24 g/dL) at a high dose of extract compared to control (11.66 ± 0.21 g/dL). P. tuber-regium extract elevated vitamin B12 of rats at high dose of extract (449.60 ± 3.12 pg/mL) compared to control (420.00 ± 2.86pg/mL). P. tuber-regium extract showed a positive response to hypoglycemic, haematinic, and vitamin level of the body and posses high calorific value. Hence P. tuber-regium can be used as good fodder, medicinal and nutritional supplement.
Co-Authors Abhaya Chandra Das Gatha Mohanty Manoranjan Prasad Sinha Mohit Das Rakesh Ranjan Rinkee Mohanty Sourav Panda Sukumar Dandapat