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All Journal Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology
Maha F. Smaism
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Medicine & Pharmacology Public Health

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Which one affect the other, Recurrent Pregnancy Loss or Serum Level of E?cadherin and c-MycBP Zena Abdul-Ameer Mahdi; Nadia M. Al-Hilli; Maha F. Smaism
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15030

Abstract

Recurrent pregnancy loss (RPL) is a foremost life event and a common pregnancy complication, whichdefined as losses of two or more pregnancies before 20 weeks of gestation. It affects approximately 1% -2% of couples trying to have children. To evaluate the potential role of cellular myelocytomatosis bindingprotein (c-MycBP) and epithelial cadherin (E-cad) serum level as biomarkers in maternal blood and focuson the similarity between tumour invasion and embryogenesis as phenomena by c-MycBP and E?cadherin.This case control study included 50 women with RPL (25 primary RPL and 25 secondary RPL) from threeinfertility clinics in Iraq. In addition to 50 control women with no history of RPL and at least one childbirth. Both groups are matched in age and BMI. Blood sampling was done for all and protein level ofc-Myc BP and E-cadherin were measured by ELISA Kit and analysis done according to the manufacturerrecommendations. The result presented in this study showed a significant difference in c?MycBP level(p<0.001) and E?cadherin (p<0.001) between patients and control. A significant positive correlation hasbeen found between these two biochemical markers (p <0.001, r=?0.39). The present study showed thatdecreasing both c-MycBP and E-cad serum level signpost possible hypothesis that these proteins participatein one way or another in RPL pathogenesis which affect cell proliferation and invasion. However, thisbinding protein transcription factor is a part of a coordinated network of various set of partners whichneed further studies in future. Taken together, additional studies are required to understand and clarify theimportance of these biomarkers on this multifactorial condition.
The Relation of Angiotensin Converting Enzyme-1 Gene with Angiotensin II and Plasminogen Activator Inhibitor in Myocardial Infarction Maha F. Smaism
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

One of the very important causes of mortality worldwide is myocardial infarction (MI). Angiotensin converting enzyme-1 (ACE-1) gene plays a principal role in converting of angiotensin-I (ANG I) to angiotensin II (ANG II).  ANG II plays necessary role in promoting of hypertension, furthermore due to the improvement of cardiovascular disease, myocardial infarction. Plasminogen activator inhibitor-1(PAI-1) play a function in modulating intravascular thrombosis, impaired fibrinolytic linked to a high level of  (PAI-1).The aim of the study is to evaluate the role of ACE-1polymorphism in level of ANG II, and the relation between plasminogen activator inhibitor-1concentration and ANG II in (MI) and hypertension patients. The study includes (100) males: 25 control, 75 patient groups, the patient group subdivided into {25  hypertensive patients for 10 years (group A), 25 hypertensive patients for 20 years(group B), 25 patients with MI+ hypertension ( group C)}, ages between (50-60 years) and BMI (18.5-24.9).The results show: There is significantly increased of ANG II, PAI-1, TG, Total cholesterol(TC), LDL-c and VLDL-c concentration, while significantly decreased of serum HDL-c in all groups of patients compared with the control group. The result observed significantly increase of ACE-1 deletion –deletion (DD)in  group  (C)  (88%) compared with the control group (44%), while there were no significantly increased in groups (A,B) compared with control group, also the result showed ACE-1 (DD) genotype was (66%), insertion-deletion (ID) genotype was (34%) and ACE insertion-insertion( II )genotype was (0%) in all study groups. And there was a positive correlation between angiotensin II and plasminogen activator inhibitor-1 in all patient groups. Conclusion: The (DD) genotype of the Angiotensin converting enzyme-1 (ACE-1) polymorphism was the most frequent among Babylon patients with myocardial infarction. This suggests that Babylon individuals with the (DD) genotype might be at high risk for myocardial infarction .Furthermore, D allele of the ACE I polymorphism might confer increased risk for MI. plasminogen activator inhibitor 1(PAI-1) may consider as a risk factor of myocardial infarction. And there was a positive correlation between angiotensin II and plasminogen activator inhibitor-1 in all patient groups. Therefore DD genotype be lead to an increase of PAI-1level.Keywords: Myocardial infarction, Angiotensin converting enzyme-1, Plasminogen activator inhibitor-1, Angiotensin II.
Association of Different Body Mass Index with Vitamin D Receptor Gene in Females with Deficiency of Vitamin D Maha F. Smaism
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Obesity is one of the well spread chronic condition that is affecting health and it is connected to many fatal chronic diseases like cardiovascular disease, diabetes mellitus and cancers. Vitamin D is shown to has a role in the pathogen city of obesity, and the Vitamin D receptor (VDR) gene polymorphism is shown to affect the obesity phenotypes like body mass index (BMI).Objective: is to assess the association between different variants of vitamin D receptor gene and the BMI in females with deficiency of vitamin D. Methods and Materials:  The study was conducted with the participation of 170      females who are having low vitamin D levels. The single nucleotide polymorphism Taq in the vitamin D receptor gene was detected by PCR-RFLP. Vitamin D level in the serum was measured by ELISA technique. Result: This study is resulted in that there is a positive correlation between the BMI and different biochemical measurements like the level of vitamin D(p < 0.001), calcium level [ both free Ca(p=0.01) and total Ca(p= 0.002)], urea level (p < 0.001), and bilirubin level (p < 0.001). It is also resulted in finding a positive correlation between the BMI and the genotype of the vitamin D receptor, as it is noticed that 44.7% of the patients who are carrying the TT genotype, while only 40.0% of the patients who are carrying the CC genotype. Conclusion From the result   the study show significantly negative correlation between Vitamin D and BMI that means the vitamin D deficiency could relate with increase BMI ,Also there is significantly negative correlation between vitamin D and cholesterol ,as well as this study indicate that significantly decrease of total bilirubin  with increasing BMI increased. From the results of genetic study for vitamin D receptor gene study, can conclude that the T allele is positively correlated to the obesity represented by the BMI, and that could lead to the conclusion that females who are having the TT genotype are of higher probability to get high  BMI and obesity. 
Co-Authors Nadia M. Al-Hilli Zena Abdul-Ameer Mahdi