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All Journal Indian Journal of Forensic Medicine & Toxicology
Qasim Azeez Razooqi
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Public Health

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Toxicity of Cadmium Chloride on White Rats Liver and the Protective Role of Brassica Nigra Seed Extract Nahla Kamal Asaad; Qasim Azeez Razooqi; Mohammed Ahmed Mustafa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15032

Abstract

The study designed for the toxic role of cadmium chloride on the liver of mice from both a physiologicaland histological aspects. The animals were treated with a dose of 5 mg/kg of body weight for 30 days. Andthe protective role of Brassica nigra seed extract against cadmium chloride toxicity. This pilot study wasconducted on 20 adult white rats divided into 4 equivalent groups including the control group: Animals inthis group received a dosed of distilled water for 30 days. The placebo group was treated with cadmiumchloride at a dose of 5 mg/kg of body weight for 30 days and returned as an infected control group. Whilein the third group, animals treated with cadmium chloride were dosed with Brassica nigra seed extractat a dose of 200 mg/kg of body weight for 30 days. The fourth group was dosed with Brassica nigraseed extract at a dose of 200 mg/kg of body weight for 30 days. After 30 days, liver enzymes includingaminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measuredby spectrophotometric method. In addition to making tissue sections of the liver. The treatment of ratsled to a significant increase (P?0.05) in liver enzymes compared with the control group. It also led tohistopathology in the liver tissue, while the Brassica nigra seed extract acted as a protective role against thetoxicity of cadmium chloride.
Co-Authors Mohammed Ahmed Mustafa Nahla Kamal Asaad