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All Journal Indian Journal of Forensic Medicine & Toxicology
Kareem Hamed Ghali
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Public Health

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The Role of HMGB1and KIM-1 Repair Genes in the Progression of Kidney Failure Disease Alyaa Abdulhadi Salih; Kareem Hamed Ghali
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15037

Abstract

Renal Failure(RF) is a leading clinical characteristic of patients in nephrology , it represents significantconcern and the main challenge for healthcare systems. The incidence rate of RF is rising globally , mainlyas a result of increased aging population. The current study , was performed to identify the effect ofHMGB1and KIM-1gene expression in renal failure disease focusing on it is role on the repair processes.This study comprises 100 patients diagnosed clinicaly and seriologicaly with renal failure )52 males and 48females ) their age vary from (17 to 80 years) and 30 healthy individuals as a control group( 18 males and12 females ). RNA extracted from blood samples and converted to cDNA which subjected to real-time PCRfor detection gene expression .HMGB1 and KIM-1 have significantly overexpression (3.51 folds and 5.37folds ) respectively in RF patients compared with healthy control subjects ( p <0.05). However , HMGB1and KIM-1 gene folding elevated gradually with advance the severity of the RF disease.
Co-Authors Alyaa Abdulhadi Salih