Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Indian Journal of Forensic Medicine & Toxicology
Hasan Ulusal
Unknown Affiliation
Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Role of oxLDL in Intrauterine Growth Restriction and Its Relationship with Thiol Homeostasis Layla Ali Shareef; Omeed Akbar Ali; Firas Shawqi Abdulrazzaq; Mehmet Akif Bozdayi; Rasha Raheem A. Alkarkoushi; Hasan Ulusal; Seyithan Taysi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15693

Abstract

Intrauterine growth restriction(IUGR) affects about 9% of whole pregnancies.It is known that there is an increased risk of mortality and morbidity in infants.It is a serious disease that causes complications such as acute and chronic pulmonary diseases, necrotizing enterocolitis, intraventricular hemorrhage and retinopathy in the future.We aimed to study the role of oxidized low density lipoprotein (OxLDL), which is an significant risk factor in cardiovascular diseases,in IUGR and its relationship with thiol homeostasis. 38 women with IUGR and 38 healthy pregnant were included in this study.Serum total thiol and native thiol levels were analyzed with fully automatic autoanalysers in patients and controls.Serum OxLDL levels were also measured by ELISA method. According to the results of the study,it was found that OxLDL was significantly higher in the patient group compared to the control group(27.29±3.32 and 10.64±1.05 ng/mL,respectively,p <0.05).However, there was no significant difference between thiol parameters(p> 0.05).In addition, there was a negative correlation between oxLDL and native thiol and OxLDL and total thiol in the IUGR group. Oxidative stress is an important factor in the formation of OxLDL.OxLDL is an effective molecule in all stages of atherosclerosis. It appears that increased oxidative stress in IUGR patients increases OxLDL.Increased OxLDL in pregnancies complicated by IUGR may increase the risk of developing cardiovascular disease for both mother and fetus later in life.Therefore, developing treatment for OxLDL in IUGR patients may protect both mother and child from future dangers.
Partial Purification of Dipeptidyl Peptidase-4 From Human Blood Serum and Study the Inhibitory Effect of Some Nitrile Derivatives on it Firas Shawqi Algburi; Nadia Y Al-Tikrity; Hasan Ulusal; Tugba Taskin-Tok
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15755

Abstract

The research includes the partial purification of dipeptidyl peptidase-4(Dpp-4) from a person’s natural serum.The enzyme was purified in three steps, precipitation by ammonium sulfate (50%), dialysis and gel filtration by Sephadex G-100. The results showed a significant increase of Dpp-4 activity and specific activity,and a decrease in total activity after purification.The descent of the purified enzyme with the highest activity from the separation column was identical to the descending of the protein with the highest activity. The inhibitory activity of nitrile derivatives that were used on the purified enzyme was studied. Nitrile derivatives were used to inhibit the activity of the Dpp-4, selected based on similarity in sites of effective groups between derivatives and anti-hyperglycemic drugs (Dpp-4 inhibitors type). The results show an inhibitory effect by the two nitrile derivatives with different concentrations.These inhibitors can work to reduce the level of blood sugar in people with diabetes. Moreover,Molecular docking was exerted to understand interaction mechanism of the compounds against Dpp-4 at atomic level based on experimental processes.
Co-Authors Firas Shawqi Abdulrazzaq Firas Shawqi Algburi Layla Ali Shareef Mehmet Akif Bozdayi Nadia Y Al-Tikrity Omeed Akbar Ali Rasha Raheem A. Alkarkoushi Seyithan Taysi Tugba Taskin-Tok