Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Juke
- Muhartono
Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Lampung
Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Pengaruh Herbisida Paraquat Dichlorida Oral terhadap Derajat Kerusakan pada Esofagus Tikus Indri Windarti; - Muhartono; I Gede Eka Widayana
JUKE Unila Vol 5, No 9 (2015)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.55 KB)

Abstract

Penggunaan herbisida di Indonesia terutama di sektor pertanian akhir−akhir ini ternyata semakin meningkat. Paraquat merupakan salah satu bahan aktif herbisida jenis gramoxone yang merupakan jenis herbisida yang paling banyak digunakan. Penggunaan paraquat dengan sembarangan dapat merusak berbagai macam organ termasuk traktus gastrointestinal. Penelitian ini bertujuan untuk mengetahui ada atau tidaknya efek paparan herbisida golongan paraquat diklorida terhadap gambaran histopatologi esofagus tikus putih  (Rattus norvegicus) jantan galur Sprague dawley. Penelitian ini adalah penelitian eksperimental laboratorik dengan desain post test only control group design. Jumlah sampel dalam penelitian ini adalah 25 ekor tikus yang terbagi kedalam 5 kelompok. K merupakan kelompok kontrol yang diberi akuades,  P1 yang diberi paraquat 25 mg/KgBB, P2 yang diberi paraquat 50 mg/KgBB, P3 yang diberi paraquat 100 mg/KgBB dan P4 yang diberi paraquat 200 mg/KgBB. Data penelitian dianalisis dengan menggunakan uji One Way ANOVA dan uji alternatifnya yaitu uji Kruskal Wallis. Sedangkan untuk melihat keeratan hubungan antar variabelnya digunakan uji Man Whitney. Hasil penelitian menunjukan ada pengaruh pemberian herbisida golongan paraquat diklorida per−oral terhadap gambaran histopatologi esofagus tikus putih (Rattus norvegicus)  jantan galur Sprague dawley (p=0,002). Hasil penelitian juga menunjukan ada pengaruh peningkatan dosis herbisida golongan paraquat diklorida terhadap derajat kerusakan esofagus tikus putih (Rattus norvegicus) jantan galur Sprague dawley. Simpulan, terdapat pengaruh herbisida paraquat dichlorida oral terhadap derajat kerusakan pada esofagus tikus. [JuKe Unila 2015; 5(9):9-12]
SNAIL’S SLIME AS AN ALTERNATIVE HYDROGEL FOR HEALING BURNS WOUND ON RATS (Rattus norvegicus) SPRAGUE DAWLEY STRAIN - Muhartono; Hendra Tarigan Sibero; Bayu Putra Danan Jaya
JUKE Unila Vol 4, No 8 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (761.027 KB)

Abstract

Background: Burns is a serious health problem that can lead to morbidity, disability, and mortality. One of the standard treatment of the burns that are known at this time is hydrogel. Despite treatment with hydrogel gives good results, it is quite expensive, so it is necessary to choose the cheaper, easier, and does not cause side effects treatment such as snail slime or mucus. This study aims to determine whether the snail mucus can act as a substitute for the hydrogel in the treatment of burns at Sprague Dawley rat strain. Method: This study is a comparative experimental study in the laboratory of Anatomical Pathology, Faculty of Medicine, Universitas Lampung, during August-November 2013. This study uses 15 white rats that were given burns, then divided into 3 treatment groups which were control group, the group given hydrogel, and the group given snail’s mucus for 14 days. Statistical analysis was performed using One Way Anova test and Post Test Hoct LSD. Result: The test results of the histopathological healing of burns showed significant differences between the hydrogel group and controls (p=0.017), while the snail mucus has no significant difference with the control group (p=0.373). Conclusion: Snail mucus can not be used as an alternative hydrogels for healing burns on white rats (Rattus norvegicus) Sprague Dawley strain. [JuKe Unila 2014; 4(8):144-150)
Co-Authors Bayu Putra Danan Jaya Hendra Tarigan Sibero I Gede Eka Widayana Indri Windarti